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Depression Clinical Trials

A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (956) clinical trials

A clinical research study evaluating an investigational drug for its safety and effectiveness in the treatment of Major Depressive Disorder Eligibility Criteria: Be 18 to 65 years old Diagnosed with Major Depressive Disorder Not getting adequate results with current antidepressant therapy Other Details: Eligible participants will receive investigational drug as ...

Phase N/A

Advancing Personalized Antidepressant Treatment Using PET/MRI

Aim 1: Determine a Pretreatment Marker of SSRI Effectiveness Using PET. With the goal of reducing MDD burden, many studies have assessed the utility of FDG-PET in antidepressant treatment prediction. However, due to the limitations listed above, there is no consensus on which brain regions are predictive of treatment efficacy. ...


Predictors of Depression Treatment Response to Exercise

50 subjects with Major Depressive Disorder who are not currently receiving treatment will be enrolled in a 12-week exercise program, supervised by a trained exercise interventionist. Blood samples will be collected at baseline for analysis of inflammatory cytokines, as well as other potential biological predictors of treatment outcomes (i.e., BDNF). ...


rTMS for MDD: 5.5cm Rule vs. F3 Targeting

Currently there is little standardization between rTMS treatment programs as to what is the best way to localize the left dorsolateral prefrontal cortex, which is the FDA-approved treatment location for clinical rTMS for major depressive disorder (MDD). Different targeting methods yield locations that can vary by up to a few ...

Phase N/A

Probiotic Supplementation in Severe Depression

Major depression is a recurrent and debilitating mental disorder with a lifetime prevalence of up to 20% in the general population, among the highest for psychiatric disorders. Its diagnosis is based upon the presence of persisting affective, cognitive and behavioural symptoms, with a depressive episode requiring at least five of ...

Phase N/A

PRogram In Support of Moms: An Innovative Stepped-Care Approach for Obstetrics and Gynecology Clinics

Upwards of 1 in 5 women suffer from depression during pregnancy or within a year after giving birth. It has negative effects on birth outcomes, infant attachment, and children's behavior/development. Maternal suicide causes 20% of postpartum deaths in depressed women. Although the vast majority of perinatal women are amenable to ...

Phase N/A

Treatment Resistant Depression and Obstructive Sleep Apnea Effect of Continuous Positive Airway Pressure (CPAP)

Primary objective: What is the effect on mood and anxiety symptoms of adding CPAP to the psychiatric treatment of patients with TRD and associated OSA? Secondary objectives: How common is co-morbid OSA in patients with treatment resistant unipolar depression referred to a tertiary Mood Disorders Clinic? Is there a difference ...

Phase N/A

Exercise and Brain Stimulation for Post-stroke Depression

This project will assess the effects of aerobic exercise training (AET), repetitive transcranial magnetic stimulation (rTMS) or their combination on depressive severity as well as locomotor function in persons with post-stroke depression (PSD). Both AET and rTMS are established stand-alone treatments for non-stroke related depression, though neither has been adequately ...

Phase N/A

Development and Assessment of a Mobile Phone Based Intervention to Reduce Maternal Depression and Improve Child Health

Disturbances in mother-infant relationship in depressed mothers negatively influence the child's development. There are a number of efficient treatments for postnatal depression including antidepressant medication, psychotherapy and psychosocial interventions. Tele-health and mobile health is a novel and emerging field in psychiatric and psychological care and treatment of mental health difficulties, ...

Phase N/A

Computer-based Treatment of Dysfunctional Beliefs in Depressive Inpatients

The aim of the present study is to investigate whether confronting depressive patients with their dysfunctional core beliefs via a computer program results in a reduction of the patients' dysfunctional beliefs. Participants will randomly be assigned to the experimental or control group. In the course of the study, experimental participants ...

Phase N/A