Depression Clinical Trials

A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 156 clinical trials
A Study of Psilocybin for Major Depressive Disorder (MDD)

One hundred participants, ages 21 to 65, who meet Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for major depressive disorder (MDD) will be stratified by study site and

major depressive disorder
severe depression
psychiatric disorder
depressive episode
  • 23 Sep, 2021
  • 7 locations
Combination of Novel Therapies for CKD Comorbid Depression

The overall goal of the study is to determine if treatment of a Major Depressive Disorder (MDD) improves the outcomes of patients with chronic kidney disease (CKD). We showed that MDD is present

glomerular filtration rate
  • 26 May, 2021
  • 3 locations
8 Week Multi-site Study of MYDAYIS for Bipolar Depression

This protocol is a Phase 2 multi-site study which aims to evaluate the safety and effectiveness of MYDAYIS® as adjunctive therapy for adults with bipolar depression. Results from this

depressive disorder
mood stabilizer
depressed mood
  • 26 Jan, 2021
  • 1 location
Clinical Outcomes With Electroconvulsive Therapy: Insights From Computational Modelling

This study will generate new information on how to optimise brain targets with ECT stimulation.

depressive disorder
major depressive disorder
depressive episode
electroconvulsive therapy
  • 22 Jan, 2021
  • 1 location
Signatures of N-Ac for Non-Suicidal Self-Injury in Adolescents

To measure NAC-induced changes to concentrations of glutathione (GSH) in the anterior cingulate cortex (ACC) as measured by magnetic resonance spectroscopy (MRS) in 36 adolescents and young adults with NSSI (12 in each group: high, low, and placebo).

n-acetyl cysteine
psychotropic drugs
  • 28 Jan, 2021
  • 1 location
Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model

The proposed study involves experimentally manipulating reproductive hormones in nonpregnant, euthymic women to create a scaled down version of the changes that occur during pregnancy and the postpartum period. This endocrine manipulation paradigm, which the investigators have shown provokes irritability in past studies, will be used to examine the neurocircuitry …

depressive disorder
structured clinical interview
major depressive disorder
axis i diagnosis
  • 02 Mar, 2021
  • 1 location
A Study of the Safety and Efficacy of SP-624 in the Treatment of Adults With Major Depressive Disorder

This is a Phase 2 clinical study evaluating the safety and effectiveness of SP-624 as compared to placebo in the treatment of adults with Major Depressive Disorder.

major depressive disorder
body mass index
  • 08 Sep, 2021
  • 33 locations
The Safety and Efficacy of Psilocybin in Cancer Patients With Major Depressive Disorder

This is a Phase II, single-center, fixed dose, open label trial to explore the safety, tolerability and efficacy of a 25mg dose of psilocybin in cancer patients with MDD. The study population will include adult men and women, 18 years of age or above, with MDD, diagnosed with a malignant …

  • 26 Jan, 2021
  • 1 location
Memory Enhancement by Gamma-hydroxybutyrate vs. Trazodone in Major Depressive Disorder.

30 healthy adults and 30 patients with major depressive disorder, will take part in three single-application pharmacological interventions (GHB vs. Trazodone vs. placebo p.o.) to test potential

major depressive disorder
  • 22 Sep, 2021
  • 1 location
A Clinical Trial of Adjunctive PRAX-114 in Participants With Major Depressive Disorder

This is a randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of 10, 20, 40 and 60 mg oral PRAX-114 as adjunctive therapy compared to placebo in the treatment of adults with MDD who had an inadequate response to their current antidepressant treatment. A sub-study to investigate …

  • 25 Jul, 2021
  • 9 locations