Depression Clinical Trials

A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 156 clinical trials
Empowerment Self-Defense Training for the Prevention of Victimization of Transgender Women

Transgender women (TW) are at the highest risk for exposure to interpersonal violence even compared to other sexual and gender minority individuals. Empowerment Self-Defense (ESD) training, a specific violence prevention approach that teaches participants strategies for actively resisting assault, holds tremendous promise for reducing risk of violent victimization. Indeed, research …

  • 01 Sep, 2021
  • 1 location
ODYSSEE-vCHAT Pilot Trial for Chronic Heart Failure

INTRODUCTION Psychological distress and reduced quality of life are prevalent in patients with chronic heart failure (CHF). The one-year rehospitalization rate is very high (40%), as well as the five-year mortality rates (45% for women and 60% for men). International task force committees report that medical therapy combined with digital …

  • 23 Aug, 2021
  • 3 locations
High-dose Vitamin D Supplements in Older Adults

This Phase II randomized clinical trial aims to test if supplementation with high dose oral vitamin D will successfully correct vitamin D insufficiency, compared to treatment with standard (RDA) dose vitamin D in a diverse community-based elderly cohort. The effect of high-dose vs. standard-dose vitamin D on altering cognitive trajectories …

  • 23 Nov, 2020
  • 1 location
A Behavioral Activation Intervention Administered in a College Freshman Orientation Course

The transition from high school to college is a developmentally sensitive period that is high risk for escalations in alcohol use. Although risky drinking is a common problem among freshmen, engagement in treatment services is very low. The proposed study will test a behavioral activation intervention that addresses factors limiting …

  • 23 Jan, 2021
  • 1 location
A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression

This study is open to adults with depression (major depressive disorder) for whom standard treatment with antidepressants alone does not work sufficiently. The purpose of the trial is to find

  • 17 Sep, 2021
  • 71 locations
Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder Including Suicidal Ideation in Pediatric Participants Assessed to be at Imminent Risk for Suicide

(oral midazolam) in rapidly reducing the symptoms of major depressive disorder (MDD) including suicidal ideation in participants 12 to less than 18 years of age who are assessed to be at imminent risk

  • 22 Sep, 2021
  • 91 locations
Clinical Trial of Fluoxetine in Anxiety and Depression in Children and Associated Brain Changes

project is to document, in pediatric anxiety disorders and major depression, perturbations in brain systems mediating attention biases, fear conditioning, emotional memory, and response to various forms

mood disorder
social phobia
behavior modification
  • 08 Sep, 2021
  • 1 location
Outcomes Mandate National Integration With Cannabis as Medicine for Prevention and Treatment of COVID-19

This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.

medical marijuana
disease or disorder
brimonidine tartrate ophthalmic solution
  • 27 Jan, 2021
  • 16 locations
A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease

The primary purpose of this study is to evaluate the effect of JNJ-63733657 versus placebo on cognitive decline using the Alzheimer's Disease Assessment Scale Cognitive subscale 13-item version (ADAS-Cog13).

cognitive decline
cognitive assessment
alzheimer's disease
  • 07 Sep, 2021
  • 149 locations
Chinese Herbal Medicine and Micronized Progesterone for Live Births in Threatened Miscarriage

Threatened miscarriage is manifested by vaginal bleeding, with or without abdominal pain, while the cervix is closed and the fetus is viable and inside the uterine cavity. Threatened miscarriage is a common complication of pregnancy occurring in 20% of all clinically recognized pregnancies and about half of these will eventually …

early pregnancy
  • 25 Jan, 2021
  • 10 locations