Depression Clinical Trials

A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 157 clinical trials
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PMZ-1620 (Sovateltide) in Mild to Moderate Alzheimer's Disease

This is a prospective, multicentric, randomized, double blind, placebo controlled Phase II clinical study to compare the safety and efficacy of PMZ-1620 therapy along with standard supportive care in subjects with mild to moderate Alzheimer's disease.

cognitive assessment
alzheimer's disease
mini-mental state examination
dementia
depression
  • 24 views
  • 06 Oct, 2021
  • 5 locations
None
Stellate Ganglion Blockade in Post-Menopausal Women

Hot flashes and night sweats (vasomotor symptoms, VMS) affect 80% of women during the menopausal transition (MT). VMS are associated with decreased quality of life, increased depressive and anxiety symptoms, memory complaints, sleep disturbance, and reduced work productivity. Hormone therapy (HT) is highly effective in reducing VMS, but the use …

paroxetine
selective serotonin reuptake inhibitor
night sweats
sleep disturbances
serum fsh
  • 68 views
  • 26 Jan, 2021
  • 3 locations
None
Dabrafenib and Trametinib Combination as a Neoadjuvant Strategy in BRAF-positive Anaplastic Thyroid Cancer

The aim of the study was to evaluate the effectiveness of combination therapy with dabrafenib and trametinib (anti-BRAF and anti-MEK inhibitors) in the neoadjuvant treatment of BRAF-positive anaplastic thyroid cancer. The prognosis in patients with ATC is poor due to the rapid and invasive tumor growth and the rapid development …

  • 0 views
  • 16 Feb, 2021
  • 1 location
None
Vortioxetine for Post-Covid-19 Syndrome

A randomized, double-blinded, placebo-controlled trial will be conducted to evaluate vortioxetine, an antidepressant with established pro-cognitive properties, for the treatment of cognitive deficits which develop during or after an infection consistent with COVID-19, continue for more than 12 weeks and are not explained by an alternative diagnosis (i.e., post-COVID-19 syndrome). …

  • 0 views
  • 01 Oct, 2021
None
Symptom Clusters in Children With Exacerbation-prone Asthma

Pediatric participants with exacerbation-prone asthma will receive an intramuscular injection of triamcinolone acetonide and will be followed for 48 weeks. The study visit 2 weeks after the injection will assess the response to the study medication, while the remaining study visits will examine the temporal stability of the symptom clusters.

  • 0 views
  • 27 Jan, 2021
  • 2 locations
None
A Study of Tolerability and Efficacy of Cannabidiol on Motor Symptoms in Parkinson's Disease

The major purpose of this study is to assess the efficacy of CBD on motor symptoms of Parkinson's Disease (PD), and secondarily to study the safety and tolerability of CBD and other efficacy, particularly regarding tremor in PD. The study has been powered to detect a clinically significant reduction in …

movement disorder
tremor
motor symptoms
  • 1 views
  • 14 Jun, 2021
  • 1 location
None
Virtual Reality-Assisted Cognitive Behavioral Therapy for Alcohol Dependence (CRAVR-Pilot)

The pilot study is a single-blinded, randomized, controlled, 2 months clinical trial. The objective is to investigate the feasibility, effects and side-effects of virtual reality-assisted cognitive behavioral therapy (VR-CBT) vs. cognitive behavioral therapy (CBT) on alcohol intake in patients with a diagnosis of alcohol dependence.

  • 0 views
  • 16 Aug, 2021
  • 1 location
None
Specifying and Treating Anxiety in Autism Research

The Specifying and Treating the Anxiety Phenotype in Autism Spectrum Disorder (STAAR) study aims to better characterize the sub-group of children and preadolescents with ASD that exhibit clinically significant anxiety by conducting a 16-week randomized comparative treatment trial of the Behavioral Intervention for Anxiety in Children with Autism (BIACA), the …

treatment regimen
speech therapy
autism
depression
selective serotonin reuptake inhibitors
  • 91 views
  • 29 Jan, 2021
  • 1 location
None
Varenicline and Bupropion for Alcohol Use Disorder

The COMB study is a randomized double-blind placebo-controlled multicenter trial in Sweden on the efficacy of varenicline and bupropion, in combination and alone, for treatment of alcohol use disorder (AUD). Study design overview: A 13-weeks (91 days) multicenter clinical trial with four parallel groups. 95 subjects per treatment arm will …

bupropion
alcohol use disorder
  • 6 views
  • 23 Jan, 2021
  • 10 locations
None
Comparing Two Treatment Combinations Gemcitabine and Nab-Paclitaxel With 5-Fluorouracil Leucovorin and Liposomal Irinotecan for Older Patients With Pancreatic Cancer That Has Spread

This phase II trial compares two treatment combinations: gemcitabine hydrochloride and nab-paclitaxel, or fluorouracil, leucovorin calcium, and liposomal irinotecan in older patients with pancreatic cancer that has spread to other places in the body (metastatic). Drugs used in chemotherapy, such as gemcitabine hydrochloride, nab-paclitaxel, fluorouracil, leucovorin calcium, and liposomal irinotecan, …

cancer
combinations
paclitaxel
tumor cells
leucovorin
  • 0 views
  • 25 Jan, 2021
  • 44 locations