Depression Clinical Trials

A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 157 clinical trials
None
Nutrition for Post-Traumatic Headache

The purpose of this multi-site study is to evaluate the efficacy of a high omega-3/low omega-6 dietary intervention (the H3-L6 Diet) vs. a Control Diet in reducing headache pain and improving function in soldiers, veterans and military healthcare beneficiaries with post-traumatic headache (PTH). In addition, the study will examine the …

  • 232 views
  • 10 Oct, 2021
  • 3 locations
None
Oxytocin to Treat PTSD

Posttraumatic stress disorder (PTSD) is a chronic, debilitating condition that disproportionately affects Veterans. Prolonged Exposure (PE) therapy is a "gold standard" treatment for PTSD. However, approximately one-third of Veterans fail to receive an adequate dose of treatment because they prematurely drop out of PE therapy. There is also room to …

mood disorder
oxytocin
anxiety
panic disorder
social phobia
  • 0 views
  • 04 Jul, 2021
  • 2 locations
None
Treating Anxiety in Parkinson's Disease With a Multi-Strain Probiotic

This study evaluates the use of an oral multi-strain probiotic in the treatment of anxiety in individuals with Parkinson's Disease. Participants will be randomized to either 12-week multi-strain probiotic treatment or placebo.

  • 0 views
  • 16 Apr, 2021
  • 1 location
None
Citalopram as a Posterior Cortical Protective Therapy in Parkinson Disease

This Parkinson disease (PD) trial will test whether 26 months of citalopram, compared to placebo, can alter the build-up of toxic amyloid-beta plaques in the visuospatial cortex of the brain linked to visuospatial cognitive impairment in PD.

cognitive impairment
dopamine
  • 0 views
  • 14 Jul, 2021
  • 1 location
None
Oxaloacetate for the Improvement of Cognitive Complaints in Stage 0-IIIA Breast Cancer Survivors

This phase II trial studies how well oxaloacetate works in reducing cognitive complaints in stage 0-IIIA breast cancer survivors. Oxaloacetate is a natural substance found in the body and is available as a nutritional supplement. Giving oxaloacetate may reduce inflammation in the brain that could be contributing to cognitive complaints …

  • 0 views
  • 15 Oct, 2021
  • 1 location
None
Radiation Therapy Palbociclib and Hormone Therapy in Treating Breast Cancer Patients With Bone Metastasis

This phase II trial studies how well radiation therapy given with standard care palbociclib and hormone therapy work in treating patients with breast cancer that has spread from one part of the body to the bone. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Palbociclib …

  • 18 views
  • 29 Sep, 2021
  • 10 locations
None
Adaptive Modification of Neoadjuvant Therapy Based on Clinical Response in Patients With Localized Pancreatic Cancer

This is an open-label, phase II study in patients with resectable and borderline resectable pancreas cancer.

neutrophil count
folfirinox
fluorouracil
gemcitabine
chemoradiotherapy
  • 7 views
  • 30 Sep, 2021
  • 1 location
None
Deciphering the Role of Oxytocin in Motivation: an fMRI Study. Part II

The proposed study will investigate the effects of intranasal oxytocin administration on neural activity associated with social and non-social motivation.

oxytocin
  • 163 views
  • 18 Jul, 2021
  • 2 locations
None
Smell in Covid-19 and Efficacy of Nasal Theophylline

Evidence of COVID-19 related anosmia and dysgeusia continues to accumulate daily. Currently, up to 80% of patients report subjective olfactory dysfunction (OD), and prevalence using objective olfactory testing could be even higher. We propose a phase II single-site, double-blinded, placebo-controlled randomized clinical trial to determine the efficacy and safety of …

  • 0 views
  • 19 Jul, 2021
  • 1 location
None
Dual-Orexin Antagonism as a Mechanism for Improving Sleep and Drug Abstinence in Opioid Use Disorder

Summary of Study Protocol. This project is designed to test neurobehavioral mechanisms underlying effects of the dual orexin-1/2 receptor antagonist suvorexant on sleep efficiency and opioid abstinence, and whether these outcomes are independent of one another. This will be the first study to investigate whether suvorexant improves outpatient opioid abstinence …

  • 0 views
  • 22 Sep, 2021
  • 1 location