Amyotrophic Lateral Sclerosis (ALS) Clinical Trials

A listing of Amyotrophic Lateral Sclerosis (ALS) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 132 clinical trials
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Epidemiology and Genetics of the Amyotrophic Lateral Sclerosis in the French West Indies

The diagnosis and the follow-up of the patients reached of SLA is centralized, since a few years, at the the Caribbean Reference center of the rare neurological diseases (CERCA lablis in 2006) in Martinique and at the Unity of coverage of the neuromuscular Diseases, SLA and the rare neurological diseases …

primary lateral sclerosis
neuromuscular diseases
  • 16 views
  • 21 Jan, 2021
  • 3 locations
None
Predictive Factors for the Diagnosis of Early Noninvasive Ventilation Equipment

To compensate for insufficiency of diagnostic tools, the present study propose to look for the predictive factors of an early fitting by noninvasive ventilation.

assisted ventilation
primary lateral sclerosis
non-invasive ventilation
  • 10 views
  • 10 Sep, 2021
  • 1 location
None
rTMS in Treatment of Spasticity

This is an open-label clinical trial to determine the safety and efficacy of rTMS in reducing spasticity and improving quality of life among patients with upper motor neuron predominant motor neuron disease (MND).

primary lateral sclerosis
edaravone
spasticity
riluzole
motor neuron disease
  • 6 views
  • 10 Oct, 2021
  • 1 location
None
Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD

The primary objective is to assess the safety and tolerability of Metformin in subjects with C9orf72 amyotrophic lateral sclerosis administered for 24 weeks. The overall objective is to determine if Metformin is safe in C9orf72 ALS patients and is a potentially viable therapeutic treatment for C9-ALS that reduces repeat-associated non-canonical …

metformin
amyotrophic lateral sclerosis
  • 43 views
  • 15 Sep, 2021
  • 2 locations
None
Conservative Iron Chelation as a Disease-modifying Strategy in Amyotrophic Lateral Sclerosis

The alteration of iron metabolism is reported in animal models of amyotrophic lateral sclerosis (ALS) as well as in sporadic and genetic forms (SOD1 and C9orf72) of ALS. The high iron

primary lateral sclerosis
maximal inspiratory pressure
spasm
fasciculation
deficit
  • 24 views
  • 25 Sep, 2021
  • 14 locations
None
Cortico-Spinal tDCS as Rehabilitative Intervention in Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease, which is a group of neurological disorders that selectively affect motor neurons, the cells that control voluntary muscles of the

neurological disorder
primary lateral sclerosis
neurodegenerative disorders
weakness
riluzole
  • 16 views
  • 18 Mar, 2021
  • 1 location
None
Treatment Continuation Study for Patients With ALS/MND Who Completed Study CMD-2019-001

Provides up to six months treatment with CuATSM for subjects who have successfully completed study CMD-2019-001

  • 0 views
  • 24 Jan, 2021
  • 1 location
None
Study of Safety and of the Mechanism of BLZ945 in ALS Patients

It is an open label study to evaluate safety, tolerability and brain microglia response in participants with ALS following multiple doses of BLZ945.

edaravone
riluzole
treatment regimen
experimental drug
positron emission tomography
  • 14 views
  • 26 Sep, 2021
  • 2 locations
None
Presymptomatic Neuromuscular Junction Defects and Compensatory Mechanisms in ALS

onset. In patients harboring genetic mutations responsible for Amyotrophic Lateral Sclerosis (ALS), identification of early, pre-symptomatic, NMJ pathological events and compensatory mechanisms could

primary lateral sclerosis
deficit
motor neuron disease
  • 0 views
  • 19 Sep, 2021
None
Explore Neuroprotective Effect of Lipoic Acid in Amyotrophic Lateral Sclerosis

In this proposed study, the investigators will evaluate the safety and efficacy of lipoic acid in treatment of Amyotrophic lateral sclerosis (ALS). The study will recruit 150 AD patients, and

riluzole
atrophy
primary lateral sclerosis
weakness
  • 0 views
  • 25 Jan, 2021
  • 1 location