Amyotrophic Lateral Sclerosis (ALS) Clinical Trials

A listing of Amyotrophic Lateral Sclerosis (ALS) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 20 clinical trials
Conservative Iron Chelation as a Disease-modifying Strategy in Amyotrophic Lateral Sclerosis

The alteration of iron metabolism is reported in animal models of amyotrophic lateral sclerosis (ALS) as well as in sporadic and genetic forms (SOD1 and C9orf72) of ALS. The high iron

iron
deficit
spasm
fasciculation
primary lateral sclerosis
  • 24 views
  • 19 Sep, 2021
  • 2 locations
Investigation on the Cortical Communication (CortiCom) System

The CortiCom system consists of 510(k)-cleared components: platinum PMT subdural cortical electrode grids, a Blackrock Microsystems patient pedestal, and an external NeuroPort Neural Signal Processor. Up to two grids will be implanted in the brain, for a total channel count of up to 128 channels, for six months. In each …

stroke
quadriplegia
surgical clearance
anarthria
primary lateral sclerosis
  • 81 views
  • 12 Sep, 2021
  • 1 location
Neurologic Stem Cell Treatment Study

This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will provide improvement in neurologic function for patients with certain neurologic conditions. …

nervous
  • 10 views
  • 18 Sep, 2021
  • 8 locations
Outcome Measures and Biomarkers in a Cohort of Spinal Muscular Atrophy Type III/ IV Patients

The "SMOB" project intends to contribute to fill the gap with reliable and operational outcome measures for type III and IV SMA. In analysing the reliability in imaging (spinal and muscular), electrophysiology analysis (MUNIX), and evaluate the evolution of respiratory function for 50 patients' cohort. The investigators would also take …

atrophy
  • 0 views
  • 12 Sep, 2021
  • 10 locations
Frequency of SOD1 and C9orf72 Gene Mutations in French ALS

The purpose of the study is to determine the frequency of mutations in the C9orf72 and SOD1 genes in the incident population of ALS patients followed in the FILSLAN centres

  • 0 views
  • 16 Sep, 2021
  • 19 locations
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American research consortium to study FTLD for 2019 and beyond.

frontotemporal dementia
progressive supranuclear palsy
primary lateral sclerosis
amyotrophic lateral sclerosis
dementia, frontotemporal
  • 79 views
  • 10 Sep, 2021
  • 23 locations
Genetic Characterization of Movement Disorders and Dementias

Background There are two basic types of movement disorders. Some cause excessive movement, some cause slowness or lack of movement. Some of these are caused by mutations in genes. On the other hand, dementia is a condition of declining mental abilities, especially memory. Dementia can occur at any age but …

cognitive impairment
genetic testing
dementia
blood tests
anemia
  • 572 views
  • 21 Sep, 2021
  • 1 location
Circulating Biomarker for Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic Lateral Sclerosis (ALS) is a rare disease with a worldwide incidence of 2-3 cases per 100,000 individuals/year and it is characterized by progressive neurodegeneration of motor

fals
primary lateral sclerosis
  • 10 views
  • 09 Sep, 2021
  • 1 location
A Study to Explore the Role of Gut Flora in ALS

This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding ALS

  • 23 views
  • 12 Sep, 2021
  • 1 location
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Background Neurodegenerative disorders can lead to problems in movement or memory. Some can cause abnormal proteins to build up in brain cells. Researchers want to understand whether these diseases have related causes or risk factors. Objective To test people with movement or thinking and memory problems to see if they …

tau protein
neurodegenerative disorders
abnormal protein
frontotemporal dementia
aphasia
  • 57 views
  • 20 Sep, 2021
  • 1 location