Amyotrophic Lateral Sclerosis (ALS) Clinical Trials

A listing of Amyotrophic Lateral Sclerosis (ALS) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 14 clinical trials
Efficacy and Safety Study of Oral Edaravone Administered in Subjects With ALS

To evaluate and compare the efficacy of two dosing regimens of oral edaravone in subjects with amyotrophic lateral sclerosis (ALS) based on the change in ALS Functional Rating ScaleRevised

primary lateral sclerosis
edaravone
  • 0 views
  • 16 Jun, 2021
  • 39 locations
HEALEY ALS Platform Trial - Master Protocol

The HEALEY ALS Platform Trial is a perpetual multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of ALS.

treatment regimen
edaravone
weakness
riluzole
  • 144 views
  • 12 Jun, 2021
  • 51 locations
RT001 in Amyotrophic Lateral Sclerosis

RT001-014 is a Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Assess Efficacy, Long Term Safety and Tolerability of RT001 in Subjects with Amyotrophic Lateral Sclerosis

primary lateral sclerosis
  • 0 views
  • 17 Jun, 2021
  • 4 locations
Safety Extension Study of Oral Edaravone Administered in Subjects With Amyotrophic Lateral Sclerosis (ALS)

in subjects with Amyotrophic Lateral Sclerosis (ALS) for up to 96 weeks.

primary lateral sclerosis
edaravone
  • 0 views
  • 15 Jun, 2021
  • 18 locations
Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease

patients with ALS (amyotrophic lateral sclerosis) and healthy controls.

amyotrophic lateral sclerosis
primary lateral sclerosis
neuromuscular diseases
  • 21 views
  • 15 Jun, 2021
  • 2 locations
Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD

The primary objective is to assess the safety and tolerability of Metformin in subjects with C9orf72 amyotrophic lateral sclerosis administered for 24 weeks. The overall objective is to determine if Metformin is safe in C9orf72 ALS patients and is a potentially viable therapeutic treatment for C9-ALS that reduces repeat-associated non-canonical …

amyotrophic lateral sclerosis
metformin
  • 41 views
  • 16 Jun, 2021
  • 2 locations
Study of Safety and of the Mechanism of BLZ945 in ALS Patients

It is an open label study to evaluate safety, tolerability and brain microglia response in participants with ALS following multiple doses of BLZ945.

experimental drug
pregnancy testing
riluzole
positron emission tomography
treatment regimen
  • 14 views
  • 14 Jun, 2021
  • 2 locations
Evaluation of MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients With ALS

A Phase 2b/3 multicenter, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy, safety and tolerability of MN-166 given to ALS participants for 12 months followed by a 6-month open-label extension phase.

swallow study
weakness
riluzole
pulmonary function test
edaravone
  • 57 views
  • 08 Jun, 2021
  • 19 locations
The NO-ALS Study: A Trial of Nicotinamide/Pterostilbene Supplement in ALS.

Amyotrophic lateral sclerosis (ALS) is a serious rapidly progressive disease of the nervous system. The average survival from the time of diagnosis is 3 years. Apart from Riluzole, there is no

progressive disease
primary lateral sclerosis
weakness
riluzole
  • 0 views
  • 13 Jun, 2021
  • 9 locations
A Study to Evaluate the Efficacy Safety Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)

The primary purpose of this study is to evaluate the clinical efficacy of ION363 on clinical function and survival in carriers of fused in sarcoma mutations with amyotrophic lateral sclerosis (FUS-ALS).

primary lateral sclerosis
edaravone
riluzole
  • 0 views
  • 19 Jun, 2021
  • 1 location