Amyotrophic Lateral Sclerosis (ALS) Clinical Trials

A listing of Amyotrophic Lateral Sclerosis (ALS) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 102 clinical trials
Featured trial
Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS) (HIMALAYA)  

This is a parallel treatment, Phase 2, randomized, double-blind study to assess the efficacy, safety, tolerability, PK, and PD of twice daily (BID) oral SAR443820 compared with placebo in male and female participants,18 to 80 years of age with ALS followed by an openlabel, longterm extension period. Study ACT16970 consists …

riluzole
primary lateral sclerosis
body mass index
edaravone
  • 40 views
  • 27 Jan, 2023
  • 18 locations
  • 8 views
  • 22 Oct, 2022
  • 27 locations
Efficacy and Safety Extension Study of Oral Edaravone Administered in Subjects With ALS

To evaluate and compare the efficacy of two dosing regimens of oral edaravone in subjects with amyotrophic lateral sclerosis (ALS), based on the time from the randomization date in Study MT-1186

  • 0 views
  • 05 May, 2022
  • 9 locations
Adenosine 2A Receptor Antagonism and AIH in ALS

intermittent hypoxia, or AIH), on breathing. This project will study breathing in people with amyotrophic lateral sclerosis (ALS) and unaffected, age-matched adults. Istradefylline is prescribed to increase

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
Evaluation of Vision-Guided Shared Control for Assistive Robotics Manipulators (ARM Control)

The purpose of this study is to evaluate a new control (i.e., the vision-guided shared control) for a wheelchair-mounted assistive robotic manipulator among powered wheelchair users. This study will consist of a questionnaire about general demographics, health information, and previous experience with assistive technology. Several tests will also be administered …

  • 0 views
  • 14 Jun, 2022
  • 1 location
Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS) (HIMALAYA)

This is a parallel treatment, Phase 2, randomized, double-blind study to assess the efficacy, safety, tolerability, PK, and PD of twice daily (BID) oral SAR443820 compared with placebo in male and female participants,18 to 80 years of age with ALS followed by an openlabel, longterm extension period. Study ACT16970 consists …

riluzole
primary lateral sclerosis
body mass index
edaravone
  • 0 views
  • 07 Oct, 2022
  • 28 locations
Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) or Frontotemporal Dementia (FTD) (FOCUS-C9)

This is a Phase 1b/2a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, PK, and PD of intrathecal (IT) WVE-004 in adult patients with C9orf72-associated ALS or FTD. To participate in the study, patients must have a documented mutation (GGGGCC [G4C2] repeat expansion) in the first intronic region …

frontotemporal dementia
primary lateral sclerosis
frontotemporal lobar degeneration
dementia
riluzole
  • 1 views
  • 07 Oct, 2022
  • 17 locations
A Study to Evaluate, Safety, Tolerability, Pharmacodynamic (PD) Markers and Pharmacokinetics (PK) of AP-101 in Participants With Amyotrophic Lateral Sclerosis (ALS)

The purpose of this study is to evaluate the safety, tolerability, PK, and PD of AP-101 in participants with fALS and sALS.

primary lateral sclerosis
weakness
assisted ventilation
riluzole
edaravone
  • 0 views
  • 04 Oct, 2022
  • 9 locations
Efficacy and Safety Study of Oral Edaravone Administered in Subjects With ALS

To evaluate and compare the efficacy of two dosing regimens of oral edaravone in subjects with amyotrophic lateral sclerosis (ALS) based on the change in ALS Functional Rating ScaleRevised

primary lateral sclerosis
edaravone
  • 1 views
  • 02 Jun, 2022
  • 94 locations
A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD

This is a Phase 2a study to assess the the safety and tolerability of TPN-101 in patients with Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD) Associated with

cognitive impairment
primary lateral sclerosis
weakness
aphasia
mental state exam
  • 2 views
  • 01 May, 2022
  • 18 locations