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Asthma Clinical Trials

A listing of Asthma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (30) clinical trials

The RECONSTRUCT Study - Reconstructing Disease Mechanisms in Asthma

Purpose and background Inhaled corticosteroids and asthma phenotypes Inhaled corticosteroid (ICS) is a cornerstone in the treatment of asthma. ICS acts locally in the airways through several pathways to limit inflammation, primarily through reduction of eosinophilic inflammation. In clinical practice however a substantial part of adult patients with asthma have ...

Phase

Clinical and Immunological Efficiency of Bacterial Vaccines at Adult Patients With Bronchopulmonary Pathology

Methods IgG-antibodies against S.pneumoniae - solid-phase ELISA. General levels of IgA, IgM, IgG, IgE in sera - radial immunodiffusion. Phagocytic activity (granulocytes, monocytes), nitroblue tetrazolium test; activated T-lymphocytes (CD3+CD69+); activated B-lymphocytes (CD3-CD69+); absolute content of leukocytes; absolute and relative content of lymphocytes, granulocytes, monocytes, T-lymphocytes (CD3+, CD4+, CD8+), B-lymphocytes (CD69+); ...

Phase

Effect of Specific Immunotherapy to Dust Mites in Children With Asthma

Specific immunotherapy is the only one causal treatment method of atopic diseases including bronchial asthma in children. The aim of the study is to assess the effect of specific immunotherapy (SIT) to dust mites on clinical symptoms,reliever drugs usage, inhaled glucocorticosteroid usage, quality of life, lung function, chosen markers of ...

Phase

Evaluation of Efficacy of House Dust Mite Immunotherapy in Children With Bronchial Asthma

According to Global Initiative for Asthma treatment of asthma is based on avoidance of allergens, pharmacological treatment, and specific immunotherapy. The aim of the study is to assess the effect of specific immunotherapy (SIT) to dust mites on clinical symptoms, reliever drugs usage, inhaled glucocorticosteroid usage, quality of life, lung ...

Phase

Assessment of Utility of Exhaled Nitric Oxide Measurement for Treatment Monitoring in Children With Asthma

Asthma is one of the most common chronic disease worldwide, imposing a substantial social burden on both children and adults. What needs to be kept in mind, especially in assessing treatment effect of allergic inflammation in children with asthma, is that symptom score and spirometry measures have limitations, mainly their ...

Phase

Rapid Onset Action of Salbutamol Versus Formoterol

It is desirable to have a single MDI that can be used as both LABA and SABA. There are few studies involving few children on use of formoterol that shows rapid bronchodilatation in children with asthma and no study that used it as rescue drug in children with acute exacerbation ...

Phase

Onset of Action of Advair Hydrofluoroalkane (HFA) 115/21 in Comparison to Symbicort Pressurised Metered-Dose Inhalers (pMDI) 160/4.5 Measured by Impulse Oscillometry (IOS)

Eligibility criteria include age 12-45 years, with current treatment of asthma with as-needed SABA only; and manifesting an acute response to SABA at screening of 40% or greater improvement in IOS low frequency reactance. After inclusion in the protocol, all subjects will receive active treatment, either with Advair or with ...

Phase

A Pilot Efficacy Study of Inhaled Albuterol Delivered With Akita Breath Control

Side effects of albuterol (salbutamol)are directly related to the dose delivered and absorbed into blood stream. By controlling aerosol delivery, dose delivered, site of deposition, amount of drug absorption can be determined and thus the magnitude of the side effects. Delivery and deposition of aerosols are determined by both aerosol ...

Phase

Bronchoprotection of Salbutamol in Asthma and Chronic Obstructive Pulmonary Disease

In asthma, the administration (inhalation) of a selective 2 receptor agonist (e.g. salbutamol), prior to methacholine challenge has been shown to shift the dose response curve to the right and "bronchoprotect" the airway against airway smooth muscle contraction. The extent of 2 receptor agonist bronchoprotection in COPD is unknown. Airway ...

Phase

Effects of a Orally Inhaled Fluticasone Furoate on Growth Velocity in Prepubertal Paediatric Subjects With Asthma Over a Year

There is a regulatory requirement to evaluate the extent of reduction (if any) of growth velocity associated with inhaled corticosteroid (ICS) containing products that are to be administered to children, and to this end there is Food and Drug Administration (FDA) regulatory guidance. This is a randomised, single-blind (run-in period)/double-blind ...

Phase