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Asthma Clinical Trials

A listing of Asthma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (34) clinical trials

C1-inhibitor in Allergic ASThma Patients

Intravenous administration of C1-inhibitor (n=20) or vehicle (n=20). One group of patients (n=20) will receive broad spectrum antibiotics (vancomycin, ciprofloxacin, metronidazole) for 7 days (washout 36 hours before study day). This group will receive the same vehicle as the control group 2 hours prior to challenge. HDM will be administered ...


Study to Assess the Efficacy and Safety of Omalizumab Treatment on ICS Reduction for Severe IgE-mediated Asthma

This is a multicentric, open label, randomized, parallel-group study with a 12-month treatment period. Patients will be assigned to one of the 2 treatment groups, omalizumab plus budesonide/formoterol or budesonide/formoterol alone. The study comprises 4 phases: During the 4-week run-in phase adult patients will receive budesonide 800 mg and formoterol ...


The RECONSTRUCT Study - Reconstructing Disease Mechanisms in Asthma

Purpose and background Inhaled corticosteroids and asthma phenotypes Inhaled corticosteroid (ICS) is a cornerstone in the treatment of asthma. ICS acts locally in the airways through several pathways to limit inflammation, primarily through reduction of eosinophilic inflammation. In clinical practice however a substantial part of adult patients with asthma have ...


Clinical and Immunological Efficiency of Bacterial Vaccines at Adult Patients With Bronchopulmonary Pathology

Methods IgG-antibodies against S.pneumoniae - solid-phase ELISA. General levels of IgA, IgM, IgG, IgE in sera - radial immunodiffusion. Phagocytic activity (granulocytes, monocytes), nitroblue tetrazolium test; activated T-lymphocytes (CD3+CD69+); activated B-lymphocytes (CD3-CD69+); absolute content of leukocytes; absolute and relative content of lymphocytes, granulocytes, monocytes, T-lymphocytes (CD3+, CD4+, CD8+), B-lymphocytes (CD69+); ...


Pneumococcal Vaccines in Patients With Asthma

Patients will be randomized into either PCV13 and PPSV23 (Experimental) or PPSV23 alone (Active comparator). At the Week 0 time point, the patients will receive either PCV13 (Experimental) or PPSV23 (Active comparator) and undergo a blood draw of 5ml for assessment of pre-vacation serotype titers. The Active Comparator group will ...


Effect of Specific Immunotherapy to Dust Mites in Children With Asthma

Specific immunotherapy is the only one causal treatment method of atopic diseases including bronchial asthma in children. The aim of the study is to assess the effect of specific immunotherapy (SIT) to dust mites on clinical symptoms,reliever drugs usage, inhaled glucocorticosteroid usage, quality of life, lung function, chosen markers of ...


Evaluation of Efficacy of House Dust Mite Immunotherapy in Children With Bronchial Asthma

According to Global Initiative for Asthma treatment of asthma is based on avoidance of allergens, pharmacological treatment, and specific immunotherapy. The aim of the study is to assess the effect of specific immunotherapy (SIT) to dust mites on clinical symptoms, reliever drugs usage, inhaled glucocorticosteroid usage, quality of life, lung ...


Assessment of Utility of Exhaled Nitric Oxide Measurement for Treatment Monitoring in Children With Asthma

Asthma is one of the most common chronic disease worldwide, imposing a substantial social burden on both children and adults. What needs to be kept in mind, especially in assessing treatment effect of allergic inflammation in children with asthma, is that symptom score and spirometry measures have limitations, mainly their ...


Rapid Onset Action of Salbutamol Versus Formoterol

It is desirable to have a single MDI that can be used as both LABA and SABA. There are few studies involving few children on use of formoterol that shows rapid bronchodilatation in children with asthma and no study that used it as rescue drug in children with acute exacerbation ...


Onset of Action of Advair Hydrofluoroalkane (HFA) 115/21 in Comparison to Symbicort Pressurised Metered-Dose Inhalers (pMDI) 160/4.5 Measured by Impulse Oscillometry (IOS)

Eligibility criteria include age 12-45 years, with current treatment of asthma with as-needed SABA only; and manifesting an acute response to SABA at screening of 40% or greater improvement in IOS low frequency reactance. After inclusion in the protocol, all subjects will receive active treatment, either with Advair or with ...