White Cell Disorders Clinical Trials

A listing of White Cell Disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 9 clinical trials
A Phase I Study of MozobilTM in the Treatment of Patients With WHIMS

Background WHIMS (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis Syndrome) is caused by various genetic changes that increase the activity of the chemokine receptor, CXCR4. Excessive function of this receptor causes mature neutrophils (part of the white blood cells) to be retained within the bone marrow rather than being released to the …

warts
severe infection
HIV Infection
aspermatogenic sterility
AIDS
  • 112 views
  • 10 Oct, 2022
  • 1 location
Pilot Study of Mepolizumab in Episodic Angioedema With Eosinophilia

Background Gleich syndrome is also called episodic angioedema with eosinophilia (EAE). People with EAE have episodes of swelling. They may also have itching, hives, fever, and weight gain. During episodes, the body has very high numbers of white blood cells, especially a kind called eosinophils. Researchers think a drug called …

angioedema
swelling
myalgias
follicle stimulating hormone
asthma
  • 12 views
  • 27 Oct, 2022
  • 1 location
Phase 1 Study of the Safety and Immunogenicity of an Epstein-Barr Virus (EBV) gp350- Ferritin Nanoparticle Vaccine in Healthy Adults With or Without EBV Infection

Background Epstein-Barr virus (EBV) causes most cases of infectious mononucleosis (mono). Up to 1 in 10 people who get mono can have fatigue that lasts more than 6 months. One out of 100 people can have severe complications. EBV is also associated with several types of cancer. Researchers want to …

Accepts healthy volunteers
cancer
  • 0 views
  • 21 Oct, 2022
  • 1 location
Natural History of Hypereosinophilia and Hypereosinophilic Syndromes (COHESION)

Unexplained chronic hypereosinophilia (HE) and hypereosinophilic syndromes (HES) are heterogeneous regarding the organ involvements (heart, lungs, skin, .. or none), the evolutionary profiles, the response to treatments. Underlying mechanisms are largely unknown and may associate genetic predisposing factors (germinal ? somatic?), environmental factors (alimentation, tobacco use, hormones, infections, ..) The …

  • 0 views
  • 12 Feb, 2022
Research Respiratory Tract Procedures

This study will collect fluid and tissue specimens from the lungs and nose of healthy people and people with a history of lung infections. The specimens will be examined for differences between the two groups that may be associated with susceptibility to certain infections. Healthy normal volunteers and people with …

Accepts healthy volunteers
sedative
blood urea nitrogen
chest x-ray
hepatitis serologies
  • 116 views
  • 21 Oct, 2022
  • 1 location
Eosinophil Activation and Function in Parasitic Infections and Other Conditions With Increased Tissue or Peripheral Blood Eosinophilia in Humans

This study will investigate how, why and under what conditions eosinophils (a type of white blood cell) become activated and will examine their function in immune reactions. Eosinophil counts often rise in response to allergies, asthma, and parasitic worm infections. They can also go up in uncommon autoimmune conditions and, …

local swelling
blood test
swelling
leukapheresis
toxic substances
  • 178 views
  • 23 Oct, 2022
  • 1 location
Investigation of the Genetics of Hematologic Diseases

The purpose of this study is to collect and store samples and health information for current and future research to learn more about the causes and treatment of blood diseases. This is not a therapeutic or diagnostic protocol for clinical purposes. Blood, bone marrow, hair follicles, nail clippings, urine, saliva …

sickle cell disease
hematologic disorder
blood disorder
sickle cell anemia
hydroxyurea
  • 112 views
  • 15 Jun, 2022
  • 1 location
A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression

Eosinophils are a type of white blood cell. Elevated eosinophil levels can damage the heart, nerves, and other organs, in the syndrome known as hypereosinophilic syndrome (HES). Some individuals have a hereditary form of HES known as familial eosinophilia (FE). More research on the causation and mechanisms of HES is …

Accepts healthy volunteers
  • 0 views
  • 13 Oct, 2022
  • 1 location
Drivers of Eosinophilic COPD Exacerbations

Main objective: investigate gene expression differences in nasal epithelium and sputum between eosinophilic COPD exacerbations and other subtypes.

  • 0 views
  • 22 Jul, 2021
  • 2 locations