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Ulcerative Colitis Clinical Trials

A listing of Ulcerative Colitis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (59) clinical trials

Efficacy of Golimumab in Maintaining Deep Remission in UC Patients in Prolonged Remission With Infliximab

Ulcerative colitis (UC) is a chronic idiopathic relapsing-remitting or continuously active inflammatory bowel disease (IBD) which almost exclusively affects the colonic mucosa. Acute severe flares of UC may lead onto potential lethal complications, such as massive haemorrhage, toxic megacolon, peritonitis, and colectomy whereas chronic active disease may lead to functional ...

Phase N/A

Multimodal Approach in IBD Patients

Patients with a confirmed diagnosis of IBD will be prospectively assessed on a yearly basis in order to assess relapse risk factors. Disease activity will be assessed using the Mayo score for UC patients and CDAI for Crohn's disease and endoscopic activity will be assessed using the Mayo endoscopic subscore ...

Phase N/A

Predicting Relapse of Ulcerative Colitis With Gastrointestinal Ultrasound

INTRODUCTION AND RATIONALE 1.1 Introduction This protocol describes PRELAPSE, an explorative, prospective, longitudinal observational study of diagnostic accuracy comparing trans-abdominal gastrointestinal ultrasound (GIUS) with ileocolonoscopy for the assessment of disease activity in patients with ulcerative colitis (UC) and with regards relapse as an outcome. 1.2 Background Ulcerative colitis is an ...

Phase N/A

Canadian Children Inflammatory Bowel Disease Network (CIDsCANN)

The National Coordinating Centre has established and maintains an encrypted Network Website that will serve as the central portal for all Network communication and data transfer. All data related to the Network is stored within a single secure data repository facility which incorporates a state-of-the-art bio-repository sample tracking system, as ...

Phase N/A

Inflammatory Bowel Disease in South Eastern Norway

The IBSEN III study will investigate the incidence of inflammatory bowel disease in South Eastern Norway and describe the clinical course of the disease. The investigators will map newly diagnosed and treatment naive IBD patients at various levels (epidemiological, clinical, psychosocial and nutritional as well as immunological, genetic, epigenetic and ...

Phase N/A

The Diversity of the Fungal and Bacterial in Colon Mucosa of Patients With Different Degree of Inflammation of Ulcerative Colitis

In recent years, the relationship of intestinal fungus with inflammatory bowel disease was gradually revealed. We divided the patients with ulcerative colitis into three groups on the basis of World Gastroenterology Organisation (WGO) classification about inflammation degree and progress classification and established the healthy control group. Analyzing the diversity of ...

Phase N/A

Immunological Profiles in Inflammatory Bowel Disease

Rationale: Inflammatory Bowel Diseases (IBD) is a heterogeneous group of diseases regarding clinical presentation, disease course and treatment response. Pathogenesis is complex and multifactorial, based on interactions between genetic and environmental factors, gut microbiota and the immune system, leading to intestinal inflammation. As the immune reaction itself causes the intestinal ...

Phase N/A

Golimumab Effect in the Modulation of Gut Microbiota in Ulcerative Colitis

Golimumab effect in the modulation of gut microbiota in Ulcerative Colitis. Pilot Study. BACKGROUND Recently, a consistent body of evidence indicates that the gut microbiota ability to modulate and direct the host immune response is considered one of the pivotal factors that modulate the delicate balance between health and disease ...

Phase N/A

OptiCal Study -Optimizing Fecal Calprotectin Monitoring: a Clinical Study Comparing CalproLab Against PhiCal and Evaluating Its Association With the Gut Microbiome

Fecal Calprotectin has become one of the most frequently used biomarkers in patients suffering from Inflammatory Bowel Diseases. Although its use for monitoring disease activity and therapeutic efficiency has previously been demonstrated, the test performance should further be optimized to improve clinical accuracy. The PhiCal test is a quantitative ELISA ...

Phase N/A

Stricture Definition and Treatment (STRIDENT) Observational Study.

Patients with asymptomatic Crohn's disease strictures will be followed prospectively for 12 months using imaging (including MRI/intestinal ultrasound) and biochemical analyses (including CRP/calprotectin). Patient's with symptomatic or asymptomatic ulcerative colitis related strictures will be followed similarly. Risk factors for progression of strictures and development of symptoms will be identified.

Phase N/A