Arthritis and Arthritic Pain Clinical Trials

A listing of Arthritis and Arthritic Pain medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 139 clinical trials
Abatacept in Individuals Who aRe Considered At Risk of Developing Inflammatory Arthritis (ARCADIA)

Phase II, single-centre, open label, two parallel arm cohort randomised controlled trial (RCT) testing abatacept in a population of anti-CCP Ab positive individuals at moderate to high risk of developing IA according to a published risk score, already followed in the observational study 'CCP: Next Generation'

  • 02 Mar, 2022
  • 1 location
The Combined Use of PRP With Lipoaspirate and/or Bone Marrow Aspirate in Osteoarthritis

To demonstrate the efficacy of the combined use of platelet-rich plasma (PRP) with lipoaspirate and/or bone marrow aspirate in osteoarthritis of major joints, and to compare the outcomes achieved using three combinations: PRP plus lipoaspirate, PRP plus bone marrow aspirate, and PRP plus both lipoaspirate and bone marrow aspirate.

  • 15 Sep, 2021
  • 1 location
RCT Comparing Robotically-Assisted vs. Manually-Executed Total Knee Arthroplasties

This study will explore if there are any difference in functional outcomes between two different surgical procedures for total knee replacement: robot-assisted versus manually-executed total knee arthroplasty.

total knee replacement
Accepts healthy volunteers
joint reconstruction
  • 22 Mar, 2022
  • 3 locations
Safety, Tolerability and Preliminary Efficacy of Multiple Intra-articular Injections of LRX712 in Patients With Knee OA

This study will explore the preliminary efficacy of multiple intra-articular injections of LRX712 by evaluating the ability of the drug to restore structural integrity of articular cartilage. Efficacy will be evaluated in the context of the systemic safety and local tolerability of the investigational drug.

  • 20 Jul, 2022
  • 4 locations
The Phosphodiesterase 3 Inhibitor Cilostazol as an Adjunct to Conventional Therapy in Patients With Osteoarthritis

Cilostazol is able to suppress the degradation of type II collagen in human chondrocytes induced by IL-1b. Cilostazol add-on for celecoxib therapy has synergistic anti-arthritic potential by inhibiting proinflammatory cytokine production in synovial fibroblasts through the IL-10/SOCS3 pathways, consequently leading to the inhibition of synovial cell proliferation and overcoming the …

primary osteoarthritis
  • 15 May, 2022
  • 1 location
Improvement of Implant Survival in Total Joint Arthroplasty of the Trapeziometacarpal Joint

The study evaluates implant survival in total joint arthroplasty of the Trapeziometacarpal (TMC) joint by monitoring the survival of different implant types using radiostereometry (RSA) evaluation of the implants.

radiostereometric analysis
joint reconstruction
  • 23 Jan, 2021
  • 1 location
Multi-Center, Non-controlled, Prospective Radiostereometric Analysis of the Pinnacle Acetabular Shell

The primary objective is to establish the mean superior cup migration of the Pinnacle Acetabular Shell using model-based RSA over the first two years post-implantation. The primary endpoint is the mean vertical subsidence (Y translation, also known as superior cup migration) at 2 years as measured with RSA. This will …

rheumatoid arthritis
traumatic arthritis
congenital hip dysplasia
  • 14 Sep, 2022
  • 2 locations
Feasibility and Safety of Geniculate Artery Embolization for Treatment of Mild to Moderate Knee Osteoarthritis

Single-arm, single-center, no sham or placebo, prospective pilot trial designed to evaluate the feasibility and safety of transcatheter arterial embolization in patients with mild to moderate radiographic knee OA. Eligible participants will receive geniculate artery embolization using Embozene™ Color-Advanced Microspheres. Patients will be followed up for a total of 12 …

knee pain
conservative management
  • 15 Sep, 2022
  • 1 location
Clinical Trial of Electroacupuncture in Axial Spondyloarthritis (E-AcuSpA) (E-AcuSpA)

Axial spondyloarthritis (AxSpA) is a chronic disease that causes severe disability and poor quality of life. Current treatment options are limited and there are still significant non-responders to current western medications. Manual acupuncture has been shown to reduce pain in patients with AxSpA. There have been reports of electroacupuncture demonstrating …

  • 14 May, 2022
  • 1 location
Functionally Aligned vs Mechanical Axis Aligned Total Knee Arthroplasty (FATKAvsMATKA)

The objective of this study is to compare clinical and radiological outcomes in robotic-arm assisted TKA using mechanical alignment (MA TKA) versus robotic-arm assisted TKA with functional alignment (FA TKA). Both FA TKA and MA TKA are performed through similar skin incisions, robotic-guidance, and use identical implants. In MA TKA, …

joint reconstruction
total knee replacement
  • 16 May, 2022
  • 1 location