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Thrombosis Clinical Trials

A listing of Thrombosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found (39) clinical trials

Oral Anticoagulant Apixaban for Treatment of Venous Thromboembolism

Patients who have developed a venous thrombosis will receive apixaban to treat and prevent a secondary thromboembolism.


Hydroxychloroquine Administration for Reduction of Pexophagy

HARP is a phase II/III, double-blind, placebo-controlled, randomized, crossover series N-of-1 study of the effect of hydroxychloroquine (HCQ) in patients with peroxisomal biogenesis disorders (PBD-ZSD). Patients eligible for the study must have a laboratory diagnosis of PEX1, PEX6 or PEX26 dependent PBD-ZSD from a CLIA or SCC-certified clinical laboratory, a …


Ticagrelor Versus Clopidogrel in Carotid Artery Stenting

Carotid artery stenting (CAS) is an emerging treatment for atherosclerotic carotid stenosis. The main adverse event is embolic stroke during the procedure. Current medical management to prevent peri-procedural embolisation consists of dual antiplatelet therapy with clopidogrel and aspirin. Ticagrelor, a novel reversible inhibitor of the platelet adenosine diphosphate receptor P2Y12, …


Mesoglycan (Prisma ) Versus Placebo in Secondary Prevention of the Superficial Venous Thrombosis

Rationale: SVT is a relatively common clinical condition, with recent evidence of association with the development of DVT and / or pulmonary embolism that has changed the perception of the risk of this disease (with conflicting data in the literature: 3-33 %). Previous natural history studies have observed that thromboembolic …


Assessment of Changes in a Novel Histological Activity Scale in Response to ARO-AAT

Approximately 12 participants will be enrolled to receive multiple subcutaneous injections of ARO-AAT. All eligible participants will require a pre-dose biopsy completed as part of the study within the screening window. All participants will undergo an End of Study (EOS) biopsy. Treated participants will be offered the opportunity to continue …


Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency

Alpha-1 antitrypsin deficiency (AATD) is the most common genetic cause of chronic obstructive pulmonary disease (COPD) and early-onset emphysema. AATD is characterized by low AAT levels; leading to excessive neutrophil elastase (NE) mediated lung destruction. Current treatment requires the periodic infusion of pooled AAT derived from human plasma, but this …


A Phase II Open-label Single-arm Study to Evaluate the Efficacy and Safety of ADSCs in Subjects With Liver Cirrhosis

One milliliter of cell suspension will be injected intrahepatically under sonographic guidance using a gauge-18 needle.


Humacyte Human Acellular Vessel (HAV) in Patients With Vascular Trauma

This is a prospective, multicenter, multi cohort, non-randomized phase 2 study in up to 40 adult patients with life or limb threatening vascular trauma which requires surgical repair. There will be a limb cohort and a torso cohort. The limb cohort will include patients who require repair of a vessel …


Sorafenib Induced Autophagy Using Hydroxychloroquine in Hepatocellular Cancer

Phase 2 study with two cohorts: Cohort 1: As second-line treatment, we will add HCQ to SOR dose the patient was tolerating at the time of progression. Cohort 2: SOR-nave patients receive SOR 400 mg by PO twice daily on Cycle1 Day1 (C1D1). On Cycle 1 Day 15, HCQ 400 …


Hypertension Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial)

The aim of this study is to determine if lowering blood pressure using FDA approved medication (antihypertensive drugs) alters brain pulsatility and reduces brain amyloid beta protein accumulation in older adults. Amyloid beta protein is high in the brain of older adults with Alzheimer's disease. Hypertension may increase brain amyloid …