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Seizure Disorders Clinical Trials

A listing of Seizure Disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (183) clinical trials

App-based Intervention for Treating Insomnia Among Patients With Epilepsy

Sleep can affect frequency and occurrence of interictal spikes and occurrence, timing, and threshold of seizure. Epilepsy can worsen sleep architecture and severity of sleep disorders. Thus, a vicious cycle is set. Certain epilepsy syndromes are so intertwined with sleep that they are considered sleep-related epilepsies. Poor sleep in epilepsy ...

Phase N/A

Intravenous Ganaxolone as Adjunctive Therapy to Treat Subjects With Status Epilepticus

This is a double-blind, randomized, placebo-controlled study to evaluate the safety, tolerability, and efficacy of adjunctive IV ganaxolone in subjects with SE. Study drug will be added to standard of care before IV anesthetic during the treatment of SE. Subjects will be screened for inclusion/exclusion criteria prior to receiving study ...


A Study in Participants With Epilepsy to Evaluate the Pharmacokinetics Safety and Tolerability of Oxcarbazepine on Padsevonil

The purpose of the study is to evaluate the effect of stable coadministered oxcarbazepine (OXC), on the pharmacokinetics (PK), safety, tolerability of padsevonil (PSL) and the plasma PK of PSL metabolites, UCB1431322-000 and UCB1447499-000, in study participants with epilepsy compared with study participants co-medicated with stable doses of levetiracetam (LEV), ...


COMETE Study : COgnitive Rehabilitation of MEmory in Temporal Epilepsy

Epilepsy is a chronic neurological disease among the most frequent ones. It causes cognitive disorders in 20 to 50 percent of patients with structural epilepsy, that is to say in connexion with an identified or presumed cerebral lesion. Compared to seizures, these cognitive disorders are a major additional factor of ...

Phase N/A

North Carolina Genomic Evaluation by Next-generation Exome Sequencing 2

The NCGENES 2 study is part of the "Clinical Sequencing Evidence-Generating Research (CSER2)" Clinical Sites with Enhanced Diversity (U01), and brings together interdisciplinary experts from across North Carolina to address questions critical to the translation of genomic medicine to the care of patients with suspected genetic disorders. In this renewal ...

Phase N/A

Direct Cortical Measurement of the Intensity and Pattern of Current Flow Produced by TDCS

Noninvasive brain stimulation (NBS) represents a promising set of tools for neurotherapeutics and rehabilitation. In a literature search, NBS has been tested for over seventy neurologic and psychiatric conditions. NBS may complement existing medical treatments, especially for neurologic indications without suitable pharmacotherapies (e.g. tinnitus, dyskinesias) or for patients with pharmaco-resistant ...

Phase N/A

Early Diagnosis of the GLUT1 Deficiency Syndrome With a Blood Based Test

The GLUT1 Deficiency Syndrome (GLUT1-DS) is a debilitating, proteiform neurometabolic disorder caused by an impairment in the glucose transporter GLUT1 at the cell surface. Patients suffer from seizures, movement disorders and intellectual disabilities. A timely diagnosis is of prime importance as this haploinsufficiency can be improved by the so-called ketogenic ...

Phase N/A

Clinical Utility of the SPEAC System: A Case Series

The primary objective is to collect preliminary data related to the clinical utility of the SPEAC System in patients with a history of motor seizures. This trial is primarily an observational investigation. This protocol describes a series of observational case studies. Each case study is intended to be interpreted independent ...

Phase N/A

A Double-Blind Trial to Evaluate Efficacy and Safety of Cannabidiol as an add-on Therapy for Treatment in Refractory Epilepsy

The purpose of this study is to assess the efficacy of the adjuvant use of cannabidiol administered twice daily in doses of 5-25 mg/kg/day through the proportion of responsive patients; that is, participants with at least 50% decrease in the frequency of epileptic seizures in the last month of the ...


Impact of SPEAC System Data on Therapeutic Decisions Related to Convulsive Seizure Patients With a New Diagnosis

This is an open label, randomized, prospective study of the impact on healthcare utilization of a surface Electromyography (sEMG) based seizure monitoring and alerting system for Veterans with a history of motor seizures (epileptic, non-epileptic or unknown) with upper extremity motor involvement, presenting with questionable spell characterization, taking place in ...

Phase N/A