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Scleroderma Clinical Trials

A listing of Scleroderma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (79) clinical trials

Outcome of Steroid Therapy for Myocardial Inflammation in Scleroderma

Primary myocardial involvement is common in scleroderma, effected to pericardium, vascular, conducting defect and especially myocardium. Cardiac MRI is widely used for assessment of cardiac involvement in scleroderma, both structural and functional pathology. Cardiac MRI has a diagnostic accuracy of 85% for the detection of myocardial inflammation. Nowadays, the treatment ...


Analysis of Cytokine Expression Pattern in Systemic Sclerosis

The mechanisms involved in the physiopathology of systemic sclerosis (SSc) are not fully understood, particularly the pattern of cytokine expression in the skin of SSc patients. These cytokines are known to play a central role in the regulation of numerous inflammatory diseases and, among them, IL-34 is the only cytokine ...

Phase N/A

Scleroderma Treatment With Autologous Transplant (STAT) Study

PRIMARY OBJECTIVES: I. To evaluate the safety and potential efficacy of high-dose immunosuppressive therapy (HDIT) followed by autologous hematopoietic cell transplantation (HCT) (without cluster of differentiation [CD]34-selection) and maintenance therapy with mycophenolate mofetil (MMF) in systemic scleroderma (SSc) patients by evaluating the effects on event-free survival (EFS) at 5 years ...


Oral Manifestations of Systemic Sclerosis

Systemic sclerosis (SSc) is a rare multisystem connective-tissue disorder characterized by three major pathological hallmarks: widespread fibrosis, vasculopathy and immunological abnormalities. As all connective tissues can be affected, this condition has multiple effects on the orofacial region. Indeed, the latter is involved in approximately 80% of SSc patients. Oral manifestations ...

Phase N/A

Clinical and Paraclinical Characteristics of the Systemic Scleroderma Cohort According to the Criteria ACR 2013 and the History of Professional Exposure or of Agricultural Environment

This study is based on a questionnaire. The data will be collected according a retrospective and prospective design : at diagnostic of the disease at the inclusion in the systemic scleroderma cohort during the annual visit (in 2017-2018-2019-2020)

Phase N/A

Novel Screening Strategies for Scleroderma PAH

Patients with scleroderma can develop heart failure due to high blood pressure in the lungs (a condition called pulmonary arterial hypertension). It is important to find pulmonary arterial hypertension early, so that it can be treated before heart failure develops. However, the tests that we now use to find the ...

Phase N/A

Proof of Mechanism Study of GSK2330811 in Diffuse Cutaneous Systemic Sclerosis

GSK2330811 is a humanized monoclonal antibody which is in development for systemic sclerosis (SSc), a rare autoimmune disease with high morbidity and mortality. Currently, there are no approved disease modifying therapies and it is an area of high unmet medical need. GSK2330811 has been shown to bind and neutralize Oncostatin ...


Scleroderma Registry & Repository at the Hospital for Special Surgery

What will be asked of you: Completion of 2 health questionnaires Donation of research bloods. This is optional, but encouraged (if possible). We also encourage patients who come for initial visits to return so follow-up data can be collected. Benefits to Patients: The HSS Scleroderma Registry gives patients the opportunity ...

Phase N/A

Autologous Stem Cell Transplantation for Progressive Systemic Sclerosis

Autologous stem cell therapy has been shown to be effective in patients with systemic sclerosis. Nevertheless treatment is associated with treatment related mortality and patients die during follow up despite successful transplantation. Intention of this trial is to improve overall survival by modifying the existing protocol used for the ASTIS ...


Analysis of the Distribution of Regulatory B Cells in Blood of Multiple Sclerosis Patients

Multiple sclerosis (MS) is a progressive immuno-inflammatory and degenerative disease of the central nervous system (CNS) and represents the second most common cause of disability in young people. The pathophysiologic mechanisms involved are complex and effective therapeutic strategies have yet to be defined. Moreover it's today evident that treatment approaches ...

Phase N/A