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Prostate Disorders Clinical Trials

A listing of Prostate Disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (806) clinical trials

Weight Management Aimed to Reduce Risk and Improve Outcomes From Radical Prostatectomy

The purpose of this study is to test how a weight management program affects substances in the blood called biomarkers that can show the presence or severity of cancer, compared to a standardized diet and exercise educational flyer.

Phase N/A

ARN-509 and Leuprolide in Intermediate and High-risk Prostate Cancer

Primary Objective: To evaluate the differential effect of neo-adjuvant leuprolide and ARN-509 on dihydrotestosterone (DHT) concentration in benign prostate tissue based on HSD3B1 genotype. Secondary Objective(s): To evaluate the differential effect of neoadjuvant leuprolide and ARN-509 on other androgen (testosterone (T), dehydroepiandrosterone (DHEA), androstenediol, 5-androstanedione (5-dione), androstenedione (AD), androsterone and ...


Molecular Mechanisms Underlying Prostate Cancer Disparities

Individual patient African American and Caucasian American prostate biopsy cores or surgical specimens will be obtained from the following procedures: transrectal ultrasound biopsy of the prostate (TRUSBxP), MR fusion biopsy, intra-operatively (IO) at the time of prostatectomy. Using cellular DNA and RNA, isolated from prostate cancer and patient-matched normal prostate ...

Phase N/A

Seoul National University Prospectively Enrolled Registry for Prostate Cancer With Active Surveillance

Prostate cancer (PCa) remains one of the most commonly diagnosed malignancies in men worldwide. Early diagnosis and definitive therapy seem to improve oncological outcomes in men with high-risk disease, but significant concerns exist in terms of the overdiagnosis and overtreatment of patients with lower-risk tumors. In this context, active surveillance ...

Phase N/A

Clinical Evaluation of the 'ExoDx Prostate IntelliScore' (EPI)

Primary Objective(s) Confirm performance of the ExoDx Prostate (IntelliScore) (EPI) utilizing a designated collection vessel for men presenting for their initial prostate biopsy with an elevated Prostate-specific antigen (2-10 ng/mL). Evaluate impact of the confirmed ExoDx Prostate (IntelliScore) on the decision to perform an initial prostate biopsy for men presenting ...

Phase N/A

Informed Decision Making Intervention in Screening for Prostate Cancer of Predominantly African American Participants in a Community Outreach Program

PRIMARY OBJECTIVES: (A) To assess the effectiveness of a proposed educational model for informed decision about Prostate Cancer in high risk men over age 40 which compares informed decision making and shared decision making (B) to improve knowledge about prostate cancer in men over age 18 OUTLINE Participants complete an ...

Phase N/A

Comparing Hypofractionated Radiotherapy Boost to Conventionally Fractionated

Additional objectives of the study for high-risk (non-metastatic) prostate cancer patients are as follows: Analysis of number of circulating tumor cells in peripheral blood as a prognostic/predictive factors for survival. Analysis of miRNA expression levels (100, 141 and 143) in peripheral blood as a prognostic and predictive factors. Evaluation of ...

Phase N/A

Prospective Evaluation of Hypofractionated Stereotactic RT Using CyberKnife for Patients With Prostate Cancer

Evaluation of the usefulness expression of selected proteins (PTEN, SMAD4, Cyclin D1, SPP1) as prognostic and predictive factors.

Phase N/A

Preference-based Comparative Study on Definitive Radiotherapy of Prostate Cancer With Protons

The hypothesis of the study is a 7.5% decrease of combined genito-urinary and intestinal side effects from 15% with photon therapy to 7.5% by the use of protons. With an alpha of 0.05 and 80% power it is therefore necessary to treat 131 patients with protons to detect such difference. ...

Phase N/A

Registry of Irreversible Electroporation for the Ablation of Prostate Cancer With Use of Nanoknife Device

This is an international prospective observational multi-center study in which data on consecutive patients for 5 years with prostate cancer who undergo IRE are collected. Data from each patient will be collected at participating centers over a 5-year period. Patients' data at baseline visit (pre-IRE), peri-operative data and follow up ...

Phase N/A