Pancreatic Disorders Clinical Trials

A listing of Pancreatic Disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 39 clinical trials
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Carbon Ion RT for Locally Advanced Pancreatic Cancer

This is an open-label randomized trial. Subjects will be randomized in a 2:1 ratio to receive carbon ion radiotherapy versus standard care for locally advanced pancreatic cancer. Subjects who receive carbon ion radiotherapy may receive additional chemotherapy afterwards, at the discretion of the treating physicians. Subjects on the control arm …

  • 0 views
  • 30 Jan, 2021
  • 1 location
None
Combination of Anti-PD-1 Antibody and Chemotherapy in Metastatic Pancreatic Cancer

The prognosis of pancreatic cancer is extremely poor. NCCN guidelines recommend FOLFIRINOX or modified-FOLFIRINOX as the first-line chemotherapeutic regimen. Studies have shown that immunotherapy with Anti-PD-1 antibody can effectively increase the response rate and prolong patient survival in a number of cancer diseases. Here investigators intend to compare the therapeutic …

breast ductal carcinoma
pancreatic ductal adenocarcinoma
adenocarcinoma
cancer chemotherapy
folfirinox
  • 11 views
  • 23 Jan, 2021
  • 1 location
None
A Phase 3 Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Heterozygous for F508del and a Minimal Function Mutation (F/MF)

The purpose of this study is to evaluate the efficacy and safety of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in CF participants who are heterozygous for F508del and a minimal function mutation (F/MF participants).

forced expiratory volume
fibrosis
tezacaftor
  • 0 views
  • 02 Dec, 2021
  • 12 locations
None
A Study to Evaluate ELX/TEZ/IVA on Cough and Physical Activity in Subjects With Cystic Fibrosis (CF)

This study will evaluate the effects of elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) on cough and physical activity using wearable technology in CF participants.

tezacaftor
ivacaftor
fibrosis
forced expiratory volume
elexacaftor
  • 0 views
  • 02 Dec, 2021
  • 4 locations
None
Tobramycin Delivered by Nebulized Sonic Aerosol for Chronic Rhinosinusitis Treatment of Cystic Fibrosis Patients

Patients with cystic fibrosis frequently develop chronic rhinosinusitis. Bacterial colonization is facilitated by a reduced mucociliary function and some previous studies suggest that the microbiology of the upper airways might influence the microbiology of the lower airway. The aim of this randomized control study is to demonstrate efficacy of antibiotic …

tobi
sweat test
antibiotics
nasal polyp
tobramycin
  • 23 views
  • 25 Jan, 2021
  • 7 locations
None
Organoid-Guided Adjuvant Chemotherapy for Pancreatic Cancer

The purpose of this study is to explore whether adjuvant chemotherapy regimens guided by organoid drug sensitivity test can improve the outcomes of pancreatic cancer. At the same time, this study will evaluate the successful establishment rate of organoid from fresh surgical specimens , and explore the concordance between drug …

cancer chemotherapy
neutrophil count
pancreatic adenocarcinoma
adenocarcinoma
carcinoma
  • 0 views
  • 29 Jun, 2021
  • 1 location
None
Timing of Start of systemIc Treatment for Asymptomatic Metastasized Pancreatic Cancer

Since patients with metastatic pancreatic cancer have a limited life expectancy, it is important to determine the timing of when to start chemotherapy in order to optimize the benefits of chemotherapy relative to the side effects. Therefore, two treatment strategies can be considered: chemotherapy started immediately at diagnosis, or delayed …

  • 0 views
  • 31 May, 2021
  • 1 location
None
A Randomized Phase III Trial Comparing Folfirinox to Gemcitabine in Locally Advanced Pancreatic Carcinoma

French national multicentric phase III trial evaluating chemotherapy with Folfirinox or gemcitabine in locally advanced pancreatic carcinoma.

celiac
neutrophil count
oxaliplatin
ct scan
adenocarcinoma
  • 28 views
  • 02 Apr, 2021
  • 72 locations
None
Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer

This phase III trial compares perioperative chemotherapy (given before and after surgery) versus adjuvant chemotherapy (given after surgery) for the treatment of pancreatic cancer that can be removed by surgery (removable/resectable). Chemotherapy drugs, such as fluorouracil, irinotecan, leucovorin, and oxaliplatin, work in different ways to stop the growth of tumor …

celiac
platelet count
oxaliplatin
pancreatectomy
fine needle aspiration
  • 92 views
  • 26 Jan, 2021
  • 179 locations
None
Perioperative or Adjuvant mFOLFIRINOX for Resectable Pancreatic Cancer

The PREOPANC-3 study is a randomized, multicenter, phase 3 trial. Patients with resectable pancreatic cancer will be randomly assigned (1:1) to 8 cycles of neoadjuvant mFOLFIRINOX followed by surgery and 4 cycles of adjuvant mFOLFIRINOX (arm 1) or to upfront surgery followed by 12 cycles of adjuvant mFOLFIRINOX (arm 2). …

fluorouracil
breast ductal carcinoma
EGFR
pancreatic ductal adenocarcinoma
oxaliplatin
  • 0 views
  • 28 Oct, 2021
  • 15 locations