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Paget's Disease Clinical Trials

A listing of Paget's Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (83) clinical trials

Novel Mechanisms and Predictors of VEGF Receptor Inhibitor- or Immune Checkpoint Inhibitor-Associated Hypertension and Cardiovascular Disease

The purpose of this study is to understand the effect of vascular endothelial growth factor tyrosine kinase (VEGF) inhibitor, immune checkpoint-inhibitor (ICI), and combination treatment on blood pressure and blood vessel function.

Phase N/A

Natural History Study of Children and Adults With Fibrolamellar Hepatocellular Carcinoma

Background Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare hepatocellular carcinoma accounting for 0.5-9% of primary liver cancer in various case series, which is usually not associated with elevated serum alpha fetoprotein (AFP) levels, is enriched in younger age groups, and is not associated with underlying liver disease. Reports on the ...

Phase N/A

Collection of Blood Bone Marrow Tumor or Tissue Samples From Patients With Cancer to Study Drug Resistance

Background Ongoing research in the Experimental and Molecular Therapeutics Sections, NCI, requires the availability of blood, serum, tumor, hair follicle and tissue samples from patients with cancer. Resistance is the underlying cause of treatment failure, and may present as acquired or intrinsic drug resistance. Patients with cancer frequently present with ...

Phase N/A

Evaluation of Urinary Exosomes Presence From Clear Cell Renal Cell Carcinoma

The primary objective is to detect urinary exosomes, by electron microscopy technique, from clear cell renal cell carcinoma due to exosome markers (CD9) and clear cell kidney cancer (CA9).

Phase N/A

Characterization of Methylation Patterns in Hepatocellular Carcinoma

This is a prospective, multi-center, observational study aimed to collect blood samples and de-identified clinical data from subjects diagnosed with HCC (cases arm) and subjects with high risk for HCC which are undergoing routine surveillance for HCC.

Phase N/A

Stereophotogrammetry of the Torso in Healthy Individuals and Patients With Scoliosis Chest Wall Deformations or Obesity

OBJECTIVE The primary objective of this project is to determine which outcome measures derived from analysis of SP images are reliable within the healthy population and can distinguish between healthy volunteers and those with scoliosis, chest wall deformities, and obesity. Secondary objectives include comparing SP outcome measures with clinical and ...

Phase N/A

AURORAX-087A: GAG Scores for Surveillance of Recurrence in Leibovich Points 5 Non-metastatic ccRCC

Non-metastatic clear cell renal cell carcinoma (ccRCC) recur in ~20% of cases within 5 years after radical surgery. Current postoperative follow-up protocols, being schematic and at best based on risk of recurrence scores, are sub-optimal for early detection of recurrences which could potentially be available for curative management. Blood and ...

Phase N/A

Follow Up Protocol for Subjects Previously Enrolled in NCI Surgery Branch Studies

BACKGROUND Patients receiving care at the NIH Clinical Center are required to be enrolled in a clinical protocol Following participation in a treatment protocol, it may be in the best interest of the patient to continue to be followed at the Clinical Center The NCI Surgery Branch conducts clinical trials ...

Phase N/A

Immune Related-adverse Events in Patients Receiving Immune Checkpoint Inhibitors

Recent evidences in immuno-oncology showed an important role of the immune system in tumor control. In fact, immune response, both innate and adaptive one, is the first defensive mechanism against cancer. However, several tumors, during their progression, develop an immune-tolerance characterized by the activation of immune inhibitory pathways including PD-1 ...

Phase N/A

Factors Influencing Cascade Testing Among Women With Hereditary Gynecological Cancers and Their Relatives

PRIMARY OBJECTIVES: I. Identify and explore factors influencing the communication of genetic testing results from probands (patients with confirmed hereditary cancer predisposition syndrome) to their first-degree relatives. (Step 1) II. Identify and explore factors influencing decision making and pursuit of cascade testing among first-degree relatives of probands. (Step 1) III. ...

Phase N/A