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Obesity Clinical Trials

A listing of Obesity medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (48) clinical trials

Fecal Microbiota Transplantation for Diabetes Mellitus Type II in Obese Patients

Study design: 30 Patients will undergo 2 FMT's from a lean donor and will be randomized into 3 types of diet groups: low fat high fiber diet (20% fat) no change in fat intake (sham diet) high fat low fiber diet (40-45% fat) The treating physicians and the patients will ...


Phase II Study of Metformin for Reduction of Obesity-Associated Breast Cancer Risk

High adiposity is a major risk factor for a number of chronic diseases, including type 2 diabetes, cardiovascular diseases, and certain types of cancer, including postmenopausal breast cancer. The increased postmenopausal breast cancer risk in women with high adiposity is likely to be attributed to multiple metabolic disturbances including altered ...


Stool Transplantation for Treatment of Insulin Resistance in Morbidly Obese Patients

The coupled disorders of morbid obesity and type 2 diabetes (T2D) are a major and growing public health problem in Canada. The Public Health Agency of Canada 2011 report, Obesity in Canada, showed that 5.1% and 2.7% of Canadians had obesity class II (body mass index (BMI) 35.0-39.9) and III ...


Blood Lipopolysaccharide (LPS) Rifaximin Study

This is a randomized, placebo controlled proof of concept study that will examine the investigational drug Rifaximin Soluble Solid Dispersion (SSD) ability to reduce gut microbiota and thereby reduce adipose inflammation and improve insulin resistance. Each subject enrolled will undergo a fat tolerance test with a high fat meal, an ...


Ginger Capsules for the Chronic Treatment of Obesity

Overweight individuals will be interviewed at baseline and after 30, 60, 90, 120, 150 and 180 days from baseline. The following measures will be assessed: body composition (fat body% and free fat body%), anthropometric measures (height, weight, body mass index, waist circumference and abdominal circumference), blood pressure, basal metabolic rate, ...


Protocol Feasibility Study of HENRY

Background Childhood obesity impacts physiological and psychological health that tracks into adulthood; increasing risk of morbidity and mortality [1, 2]. It incurs significant costs on the UK economy, with an expected 7-fold increase in related NHS costs by 2020, and forecasted 2 billion annual spend by 2030[3]. Tackling obesity is ...


Prevention of Comorbid Depression and Obesity in Attention-deficit/ Hyperactivity Disorder

The risk for comorbid major depressive disorder and obesity is increased in adolescents and adults with attention-deficit/ hyperactivity disorder (ADHD), and adolescent ADHD predicts adults major depressive disorder and obesity. Nonpharmacological interventions to prevent these comorbidities are urgently needed. Bright light therapy (BLT) improves day-night rhythm and is an established ...


Impact of Diet and Exercise Activity on Pregnancy Outcomes

Impact of lifestyle intervention on excessive gestational weight gain


The Addition of Probiotic Consumption to a Nutritional Intervention and Caloric Restriction on Body Weight and Composition in Overweight Participants

Limited interventional human studies suggest that probiotic supplementation may be a beneficial strategy for promoting weight loss when added to a nutritional intervention via their effects on lipid absorption and metabolic signaling molecules. The purpose of this study is to evaluate the effects of addition of a probiotic supplementation to ...


Enhancing Weight Loss Maintenance With GLP-1RA (BYDUREON ) in Adolescents With Severe Obesity

Primary Objective Evaluate the effect of GLP-1RA treatment on the maintenance of weight loss and durability of cardiometabolic risk factor improvements among adolescents with severe obesity following a meal replacement induction period. The investigators hypothesize that adolescents with severe obesity receiving GLP-1RA treatment following a short-term meal replacement induction period ...