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Obesity Clinical Trials

A listing of Obesity medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (38) clinical trials

The Relationship Between Exercise Frequency Intensity and Restoration of Cardiometabolic Health

Involvement in regular physical activity is known to elicit systemic adaptations and reduce the risk of cardiometabolic diseases, including hypertension, obesity, dyslipidemia, and hyperglycemia. Traditional physical activity recommendations suggested 150 minutes of moderate-intensity continuous endurance (END) exercise dispersed over 5 days per week was sufficient to improve physical fitness in ...

Phase N/A

Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes

BACKGROUND Insulin resistance (IR) plays a major role for the increased risk of cardiovascular disease (CVD) in obesity and type 2 diabetes (T2D). Targeted treatment of IR in affected tissues is, however, almost non-existing, except for weight-loss and physical activity. The central hypothesis of this proposal is that abnormalities in ...

Phase N/A

A Nutrition and Parenting Program for Fathers and Their Pre-school Age Children

All participants (low-income father and child dyads) will receive an 8 session (2 hours/session) (DAD) including community-based, hands-on, nutrition and parent education intervention with between-session technology enhancements. Dyads will be randomly assigned within groups of 10 to DAD or a wait-list control group (DELAY). Assessments will be conducted at pre, ...

Phase N/A

Diet and Exercise Program to Promote Weight Loss and Improve Health in Men With Low- or Low-Intermediate-Risk Prostate Cancer

PRIMARY OBJECTIVES: I. To test whether the Diabetes Prevention Program (DPP) lifestyle intervention (versus [vs.] control) improves serum fasting glucose. II. To test whether the DPP lifestyle intervention (vs. control) improves serum biomarkers of glucose regulation (insulin, C-peptide, insulin-like growth factor-1 [IGF-1], IGF binding protein 3 [IGF-BP3] and adiponectin). III. ...


Mirabegron and Brown Adipose Tissue

In the current study, the effect of one single dose of Mirabegron (200 mg) versus placebo and cold-exposure will be studied in health young (18-30 years) Dutch South Asian (n=10) and Dutch Caucasian (n=10) men. All study subjects will be screened. If the subject meets all the inclusion criteria, is ...


Exenatide and Brown Adipose Tissue

The current study is an open-label single arm prospective design, including 24 healthy young lean males (BMI between 18 and 25 kg/m2), of whom 12 Dutch South Asians and 12 Dutch Caucasians. After a medical screening, included subjects will receive 12 weeks of treatment with the GLP-1 analogue exenatide (Bydureon; ...


Sildenafil Activates Browning of White Adipose and Improves Insulin Sensitivity

The study subjects will be taken placebo (first stage) and sildenafil (second stage) intervention for 7 days, respectively afterward.Subcutaneous fat tissue and muscle samples will be obtained by biopsy from some individuals and measure the browning of white adipose tissue and insulin signaling.The insulin sensitivity will be tested by insulin ...


Neuromolecular Risk Factors for Obesity (PROSPECT)

Diet, nutrition, and physical exercise are critical factors in the maintenance of good health through the entire life course. However, in most western countries the annual increase in the prevalence and the severity of obesity and physical inactivity is substantial. Early detection of individuals with high risk for obesity is ...

Phase N/A

Weight Management Aimed to Reduce Risk and Improve Outcomes From Radical Prostatectomy

The purpose of this study is to test how a weight management program affects substances in the blood called biomarkers that can show the presence or severity of cancer, compared to a standardized diet and exercise educational flyer.

Phase N/A

The Tailgate Study: A Pilot Study Measuring the Impact of Acute Alcohol Intake on Intrahepatic Lipid

Subjects will participate in a single screening visit and a 24 hours in-patient stay at the clinical research center for treatment and tests. No drugs will be used in this study, however, amounts of alcohol will be consumed to achieve, and maintain a breath alcohol at the legal limit (0.10). ...

Phase N/A