Myasthenia Gravis (Chronic Weakness) Clinical Trials

A listing of Myasthenia Gravis (Chronic Weakness) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 26 clinical trials
A Phase 3 Open-Label Study of Eculizumab in Pediatric Participants With Refractory Generalized Myasthenia Gravis (gMG)

The purpose of this study is to evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of eculizumab in the treatment of pediatric refractory gMG based on change from Baseline in the Quantitative Myasthenia Gravis (QMG) score for disease severity.

neostigmine
igiv
anticholinesterase agents
immunosuppression
repetitive nerve stimulation
  • 18 views
  • 18 Jul, 2021
  • 15 locations
The Curative Effect of Extended Thymectomy Performed Through Subxiphoid-right VATS Approach With Elevation of Sternum

Extended thymectomy is the main treatment for thymoma and other anterior mediastinal diseases. Video-assisted thoracic surgery(VATS) plays an important role in the surgery of extended thymectomy. Now, VATS thymectomy through intercostal approach has been the commonly used minimally invasive surgical procedure for thymus surgery and is applied worldwide. But the …

mediastinal diseases
thymectomy
thymic neoplasm
thymoma
anterior mediastinum
  • 21 views
  • 15 May, 2021
  • 4 locations
Autologous Peripheral Blood Stem Cell Transplant for Neurologic Autoimmune Diseases

This phase II trial studies the side effects and how well carmustine, etoposide, cytarabine and melphalan together with antithymocyte globulin before a peripheral blood stem cell transplant works in treating patients with autoimmune neurologic disease that did not respond to previous therapy. In autoimmune neurological diseases, the patient's own immune …

vasculitis
autoimmune disease
biomarker analysis
nervous
malignancy
  • 155 views
  • 26 Apr, 2021
  • 3 locations
Study of ALXN1830 Administered Subcutaneously in Adults With Generalized Myasthenia Gravis

This study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics (PD), immunogenicity, and efficacy of subcutaneous (SC) ALXN1830 in adults with generalized myasthenia gravis (gMG).

immunoglobulin g (igg)
generalized myasthenia gravis
serologic test
acetylcholine
azathioprine
  • 0 views
  • 06 Aug, 2021
  • 1 location
Clinical Trial Comparing Two Non-Surgical Treatments for Severe Blepharoptosis

This clinical trial will evaluate two non-surgical devices designed to improve eye lid opening for patients with severe Blepharoptosis (incomplete opening of the eyelids).

mental state exam
brimonidine tartrate ophthalmic solution
  • 0 views
  • 01 Aug, 2021
  • 1 location
The EXPLORE MG Registry for Myasthenia Gravis

The purpose of this study is to create a Yale University Department of Neurology Myasthenia Gravis (MG) registry that will be used for current and future research projects involving the study of Myasthenia Gravis.

  • 2 views
  • 26 Jan, 2021
  • 1 location
Clinical Prognosis and Progression of Myasthenia Gravis Patients

This study collects the clinical data of myasthenia gravis (MG) patients, assesses outcomes and adverse effects of different treatment regimens, and searches for risk factors of conversion to generalized MG.

plasma exchange
antibody test
immune globulin
igiv
immunosuppressive agents
  • 0 views
  • 02 Sep, 2021
  • 1 location
The Impact of Myasthenia Gravis in the Real World

An international, non-interventional, prospective, community recruited, longitudinal, lifestyle study which aims to collect Real-World Evidence (RWE) from people living with myasthenia gravis (MG) in order to map the disease's natural history, its burden on patients and their families, its treatment, as well as its medical, social and pharmacoeconomic impact.

  • 0 views
  • 30 Apr, 2021
  • 1 location
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help advance treatments and cures …

other disease
rare diseases
  • 4 views
  • 08 Sep, 2021
  • 2 locations
A Pilot Study to Explore the Role of Gut Flora in Myasthenia Gravis

This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.

  • 13 views
  • 12 Sep, 2021
  • 1 location