Myasthenia Gravis (Chronic Weakness) Clinical Trials

A listing of Myasthenia Gravis (Chronic Weakness) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 14 clinical trials
Myasthenia Gravis Inebilizumab Trial (MINT)

Randomized, double-blind, placebo-controlled, Phase 3, parallel-group study with optional open-label extension.

mycophenolate mofetil
corticosteroids
anti-musk antibody
immune globulin
azathioprine
  • 12 views
  • 22 Apr, 2022
  • 77 locations
Study of Pyridostigmine With Ondansetron in Subjects With Anti-AchR Positive Myasthenia Gravis

This is a phase II, single center, randomized, double-blind, placebo-controlled, study in patients with a diagnosis of anti-AchR antibody positive myasthenia gravis.

pyridostigmine
immune globulin
ondansetron
  • 14 views
  • 15 May, 2022
  • 1 location
Safety And Efficacy Of Tofacitinib In Patients With Refractory Myasthenia Gravis: A Pilot Study

This is a 6 month study that will evaluate the efficacy of 5mg tofacitinib tablet taken twice a day in patients with refractory myasthenia gravis. Twenty adult participants will receive a four month treatment of tofacitinib followed by elution for one month.

immunosuppressive agents
weakness
repetitive nerve stimulation
tacrolimus
tofacitinib 5 mg
  • 10 views
  • 07 Oct, 2022
  • 1 location
Autologous T-Cells Expressing A Chimeric Antigen Receptor Directed To B-Cell Maturation Antigen (BCMA) In Patients With Generalized Myasthenia Gravis (MG)

This is a Phase Ib/IIa study to evaluate the safety and preliminary efficacy of Descartes-08 CAR T-cells in patients with Generalized Myasthenia Gravis

immunosuppressive agents
generalized myasthenia gravis
  • 0 views
  • 25 Oct, 2022
  • 7 locations
The Curative Effect of Extended Thymectomy Performed Through Subxiphoid-right VATS Approach With Elevation of Sternum

Extended thymectomy is the main treatment for thymoma and other anterior mediastinal diseases. Video-assisted thoracic surgery(VATS) plays an important role in the surgery of extended thymectomy. Now, VATS thymectomy through intercostal approach has been the commonly used minimally invasive surgical procedure for thymus surgery and is applied worldwide. But the …

mediastinal diseases
thymic neoplasm
vats
thymectomy
anterior mediastinum
  • 22 views
  • 12 Feb, 2022
  • 5 locations
Autologous Peripheral Blood Stem Cell Transplant for Neurologic Autoimmune Diseases

This phase II trial studies the side effects and how well carmustine, etoposide, cytarabine and melphalan together with antithymocyte globulin before a peripheral blood stem cell transplant works in treating patients with autoimmune neurologic disease that did not respond to previous therapy. In autoimmune neurological diseases, the patient's own immune …

cell counts
hematopoietic stem cell transplantation
myoclonus
spinal cord disease
cerebellar degeneration
  • 214 views
  • 11 Jul, 2022
  • 3 locations
Clinical Prognosis and Progression of Myasthenia Gravis Patients

This study collects the clinical data of myasthenia gravis (MG) patients, assesses outcomes and adverse effects of different treatment regimens, and searches for risk factors of conversion to generalized MG.

immunoglobulins
immunosuppressive agents
plasma exchange
pyridostigmine
igiv
  • 0 views
  • 21 Feb, 2022
  • 1 location
The EXPLORE MG Registry for Myasthenia Gravis

The purpose of this study is to create a Yale University Department of Neurology Myasthenia Gravis (MG) registry that will be used for current and future research projects involving the study of Myasthenia Gravis.

  • 32 views
  • 06 Feb, 2022
  • 1 location
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford (CoRDS)

CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help advance treatments and cures …

other disease
rare diseases
  • 4 views
  • 15 Jul, 2022
  • 2 locations
A Pilot Study to Explore the Role of Gut Flora in Myasthenia Gravis

This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.

  • 13 views
  • 28 Feb, 2022
  • 1 location