Musculoskeletal Diseases Clinical Trials

A listing of Musculoskeletal Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 1913 clinical trials
Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery

This study evaluates whether ketamine, given as part of an anesthetic, improves depression symptoms in depressed patients undergoing total joint replacement surgery. Half of participants will receive a ketamine infusion during surgery, while the other half will receive a placebo (normal saline) during surgery.

  • 28 Mar, 2021
  • 1 location
An Imaging Framework for Clinically Testing New Treatments to Prevent Post-traumatic OA

The immediate goal of the proposed research is to test the value of a new low-cost, low-dose standing CT system for efficient early detection of both joint degeneration and elevated contact stress. The standing CT scanner holds promise for detecting arthritic changes earlier than other imaging modalities because of the …

intra-articular fracture
other imaging modalities
ankle fracture
arthritic changes
  • 25 Jan, 2021
  • 1 location
Iron Supplementation in Hip/Knee Surgery (Emacrit Plus)

Randomized controlled trial to evaluate the efficacy of oral iron supplementation plus cofactors in reducing the prevalence of preoperative anemia in a cohort of 60 patients undergoing elective prosthetic hip or knee surgery.

  • 16 May, 2021
  • 1 location
Multimodal Imaging of Subchondral Bone in Knee Osteoarthritis : Predictive Model

Predictive factors of osteoarthritis progression are not yet well understood. However, a growing role attaches importance to the subchondral bone. The aim of the present project is to determine predictive factors of progression of osteoarthritis at the knee by a multimodal characterization of subchondral bone by Medical Resonnance Imaging, direct …

  • 18 Feb, 2021
  • 3 locations
Vertebral Body Tethering Treatment for Idiopathic Scoliosis

This study will determine whether vertebral body tethering is a safe and feasible method of treatment for pediatric idiopathic scoliosis.

spina bifida
anterior vertebral body tethering
spina bifida occulta
idiopathic scoliosis
  • 23 Jan, 2021
  • 1 location
Fibromyalgia Integrative Training for Adolescents With Juvenile Fibromyalgia

This study evaluates whether Fibromyalgia Integrative Training program for Teens (FIT Teens), a combined cognitive behavioral therapy and neuromuscular exercise training program is more effective in reducing disability in adolescents with Juvenile Fibromyalgia compared to cognitive behavioral therapy (CBT) alone or a graded aerobic exercise (GAE) program alone. One third …

aerobic exercise
behavioral therapy
cognitive therapy
  • 25 Feb, 2021
  • 8 locations
RSA-RCT: Attune S+ TKA Versus Sigma TKA

The PFC Sigma Knee by DePuy Synthes is an excellent knee replacement with an excellent clinical track record, good survival rates (98% 10 years survival in patients aged < 55 years) and minimal early migration as measured with RSA (0.5mm MTPM at two years follow-up). The Attune Knee by DePuy …

  • 23 Jan, 2021
  • 1 location
Glasdegib for Chronic Graft-Versus-Host Disease

This phase I/II trial studies whether glasdegib is helpful in treating sclerosis associated with chronic graft-versus-host disease. It will also investigate the safety of glasdegib in treating patients with chronic graft-versus-host disease.

systemic therapy
neutrophil count
platelet count
  • 12 Sep, 2021
  • 4 locations
Chronic Transcranial Direct Current Stimulation in Patients With Systemic Autoimmune Myopathies

Systemic autoimmune myopathies are rheumatic diseases that affect the striatum skeletal muscles. The transcranial direct current stimulation technique has been frequent, for example, in patients with ischemic stroke or for the optimization of muscular performance in athletes. However, to date, there are no studies evaluating this technique in patients with …

  • 27 May, 2021
  • 1 location
Leflunomide for Musculoskeletal GVHD After Allogeneic Stem Cell Transplant

Graft versus host disease (GVHD) is a well-known complication of allogeneic transplant. In GVHD, the cells of the donor attack the patient's tissues and cause damage. It can affect any organ or system of the body. In a proportion of patients, it affects the joints and muscles. This is known …

  • 28 Jun, 2021
  • 1 location