Musculoskeletal Diseases Clinical Trials

A listing of Musculoskeletal Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 132 clinical trials
A Study of Oral Upadacitinib Tablets to Assess Treatment Patterns Achievement of Treatment Targets and Maintenance of Response in Adult Participants With Moderate to Severe Rheumatoid Arthritis

Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. Despite the range of treatment options for RA steadily increasing, many patients remain sub-optimally managed, with sustained clinical remission rarely achieved. This study will assess the treatment patterns, achievement of treatment …

stiffness
glucocorticoids
prednisone
remission
  • 7 views
  • 15 Sep, 2021
  • 234 locations
A Study of LY3462817 in Participants With Rheumatoid Arthritis

The reason for this study is to see if the study drug LY3462817 is safe and effective in participants with moderately to severely active rheumatoid arthritis (RA).

DMARD
rheumatoid factor
rheumatism
biologic disease-modifying antirheumatic drug
antirheumatics
  • 6 views
  • 12 Sep, 2021
  • 37 locations
Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis

The RESET-RA study will assess the safety and efficacy of the SetPoint System (study device) for the treatment of adult patients with active, moderate to severe rheumatoid arthritis who have had an inadequate response or intolerance to biologic or targeted synthetic Disease-Modifying Anti-Rheumatic Drugs (DMARDs). The study device contains a …

DMARD
antirheumatics
  • 0 views
  • 17 Sep, 2021
  • 24 locations
CEQUA for Sjogren's Syndrome Dry Eye

The primary objective of this study is to show that CEQUA (cyclosporine 0.09% ophthalmic solution) improves symptoms of dry eye disease in a population of patients with Sjogren's Syndrome diagnosis.

  • 0 views
  • 15 Sep, 2021
  • 1 location
Biomarker Development for Muscular Dystrophies

Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies. The investigators are interested in finding less invasive methods that reduce the need for muscle biopsies. The purpose of this research is to learn about the possibility …

  • 0 views
  • 03 Sep, 2021
  • 5 locations
The Pathogenesis and Natural History of Sjogren s Syndrome

Background -Sjogren s syndrome is a disease that affects about 1-4 million Americans. It is more common in women. It mainly affects the glands that produce saliva and tears, leading to dry eyes and dry mouth. The cause of Sjogren s syndrome is unknown, but inflammation plays an important role. …

keratoconjunctivitis sicca
fatigue
dry eyes
arthritis
vasculitis
  • 684 views
  • 15 Sep, 2021
  • 1 location
Characterization of Diseases With Salivary Gland Involvement

Background Salivary glands in and around the mouth and throat make saliva. Salivary gland disorders can affect a person s quality of life. Studying people who have a disease that affects their salivary gland(s) may teach researchers about the disorders and their genetics. Objectives To study salivary gland diseases and …

cancer treatment
cancer
dry eyes
  • 217 views
  • 18 Sep, 2021
  • 1 location
Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1)

Building on previous work of the Myotonic Dystrophy Clinical Research Network (DMCRN), the present study seeks to overcome insufficient data on natural history; lack of reliable biomarkers; and incomplete characterization and limited biological understanding of the phenotypic heterogeneity of Myotonic Dystrophy 1 by examining strategies to improve the reliability by …

genetic testing
genetic analysis
myotonic dystrophy
weakness
  • 11 views
  • 07 Sep, 2021
  • 19 locations
Studies of States With Resistance to Vitamin D and Parathyroid Hormone

Patients with confirmed or suspected states with resistance to vitamin D or parathyroid hormone (PTH) will be admitted for diagnosis, treatment review with suggestions for modifications to the current or new treatment and for inclusion in other protocols. These states include hypocalcemia, rickets, osteomalacia, pseudohypoparathyroidism. Resistance to a factor is …

vitamin d
parathyroid hormone
vitamin
calcium
  • 220 views
  • 17 Sep, 2021
  • 1 location
Correlation of the Inflammatory Parameters With Pain and Radiological Findings in Coxarthrosis

Osteoarthritis (OA) is a functional disease with joint degeneration with subchondral and periosteal lesions. Coxarthrosis (or hip osteoarthritis) is an important cause of disability, especially in the advanced age group.Although hip osteoarthritis is often thought to be a non-inflammatory pathology, recent studies have shown that joint degeneration is correlated with …

osteoarthritis
  • 0 views
  • 05 Sep, 2021
  • 1 location