Musculoskeletal Diseases Clinical Trials

A listing of Musculoskeletal Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 134 clinical trials
Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Rheumatoid Arthritis (RA)

Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. This study evaluates how safe and effective ABBV-154 is in participants treated for moderately to severely active RA. Adverse events and change in the disease activity will be assessed. ABBV-154 is …

antirheumatics
stiffness
methotrexate
rheumatism
  • 11 views
  • 12 Sep, 2021
  • 315 locations
Smart Marker Annunciating Response to Rheumatologic Treatments SMART T

European recommendations indicate to start a conventional synthetic disease modifying antirheumatic drug (csDMARD) as soon as possible to reach the remission in early RA or low disease activity in established RA. If the target is not achieved with the first csDMARD and in presence of poor prognostic, addition of a …

DMARD
remission
methotrexate
antirheumatics
  • 0 views
  • 17 Sep, 2021
  • 15 locations
Splenic Stimulation for RA

This study will evaluate the safety, tolerability, and effects of stimulating the splenic neurovascular bundle (NVB) with the Galvani System, which consists of a lead, implantable pulse generator, external components and accessories. The study will consist of 4 study periods, including a Randomized Control Trial period (Period 1), an Open …

baricitinib
DMARD
tumor necrosis factor
  • 8 views
  • 03 Sep, 2021
  • 4 locations
The Effect of Central Sensitization on Treatment Response in Patients With Fibromyalgia

Central sensitization (CS) is as increased response to normal or sub-threshold stimuli of central nervous system and its close relationship with fibromyalgia has been demonstrated in several studies. However, the effect of initial CS severity on treatment response in these patients is not fully known. In this study, it was …

duloxetine
  • 0 views
  • 04 Sep, 2021
  • 1 location
Acute Response to Exercise in Patients With Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the joints, causing pain, edema, physical disability and poor quality of life. In addition, RA patients are at increased risk of developing cardiovascular disease (CVD) and premature death. The most effective pharmacological treatment is the use of biological agents that …

edema
tocilizumab
tumour necrosis
tumor necrosis factor
  • 0 views
  • 04 Sep, 2021
  • 1 location
Microbiota Analysis to Predict Outcomes of Rheumatoid Arthritis Patients Treated With JAK-inhibitor

Personalized medicine in which each patient would receive the ideal personalized treatment and regimen, holds great promise to improve patient's care. However, previous studies failed to establish validated predictors of response to disease-modifying anti-rheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA). JAK inhibitors is a new class of DMARDs …

tofacitinib
baricitinib
antirheumatics
tumor necrosis factor
methotrexate
  • 0 views
  • 07 Sep, 2021
  • 1 location
Comparing of the Pharmacokinetic Safety and Immunogenicity of HS-20090-2 Injection and Prolia in Healthy Adults

A randomized, single-blind and parallel group study to compare the pharmacokinetic, safety and immunogenicity of HS-20090-2 60mg#1ml#and Prolia in healthy adults.

x-rays
prolia
  • 0 views
  • 04 Sep, 2021
  • 1 location
Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis

The RESET-RA study will assess the safety and efficacy of the SetPoint System (study device) for the treatment of adult patients with active, moderate to severe rheumatoid arthritis who have had an inadequate response or intolerance to biologic or targeted synthetic Disease-Modifying Anti-Rheumatic Drugs (DMARDs). The study device contains a …

DMARD
antirheumatics
  • 0 views
  • 17 Sep, 2021
  • 24 locations
Auriculotherapy Treatment in Fibromyalgia

Fibromyalgia (FM) is the most common cause of diffuse pain in the bones and joints, and one of the most frequent causes of referral to the pain management unit. It affects mainly women; they are referred by a rheumatologist, an internal medicine physician or by their family physician. FM produces …

anxiety
fatigue
depression
analgesia
sleep disorder
  • 960 views
  • 08 Sep, 2021
  • 1 location
A Safety Efficacy And Pharmacokinetics Study Of Tofacitinib In Pediatric Patients With sJIA

A randomized withdrawal study in which responders to open-label treatment with tofacitinib will be randomized in a 1:1 ratio to tofacitinib or placebo in a double-blind phase. In the double-blind phase "time to sJIA flare" will be evaluated as primary endpoint and subjects will be discontinued once they experience sJIA …

  • 134 views
  • 04 Sep, 2021
  • 101 locations