Musculoskeletal Diseases Clinical Trials

A listing of Musculoskeletal Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 132 clinical trials
A Study of Guselkumab in Participants With Active Psoriatic Arthritis

The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA.

NSAID
apremilast
rheumatoid nodules
polyarticular arthritis
arthritis mutilans
  • 14 views
  • 10 Sep, 2021
  • 217 locations
Pinnacle RSA Study

The primary objective is to establish the mean superior cup migration of the Pinnacle Acetabular Shell using model-based RSA over the first two years post-implantation. The primary endpoint is the mean vertical subsidence (Y translation, also known as superior cup migration) at 2 years as measured with RSA. This will …

congenital hip dysplasia
rheumatoid arthritis
traumatic arthritis
  • 5 views
  • 15 Sep, 2021
  • 3 locations
The Combined Use of PRP With Lipoaspirate and/or Bone Marrow Aspirate in Osteoarthritis

To demonstrate the efficacy of the combined use of platelet-rich plasma (PRP) with lipoaspirate and/or bone marrow aspirate in osteoarthritis of major joints, and to compare the outcomes achieved using three combinations: PRP plus lipoaspirate, PRP plus bone marrow aspirate, and PRP plus both lipoaspirate and bone marrow aspirate.

x-rays
  • 42 views
  • 15 Sep, 2021
  • 1 location
Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Osteoarthritis

This study is being done to test the safety and efficacy of LY3556050 for the treatment of osteoarthritis pain. This trial is part of the chronic pain master protocol (H0P-MC-CPMP) which is a protocol to accelerate the development of new treatments for chronic pain.

body mass index
knee pain
chronic pain
x-rays
  • 22 views
  • 12 Sep, 2021
  • 46 locations
Psoriasis Longitudinal Assessment and Registry

The purpose of this study is to further evaluate the safety of infliximab, ustekinumab, and guselkumab in patients with plaque and other forms of psoriasis. The study also includes patients receiving other therapies, such as non-biologic and other biologic agents. The registry also evaluates patient and disease characteristics, including patient-reported …

ixekizumab
secukinumab
infliximab
acitretin
guselkumab
  • 4040 views
  • 07 Sep, 2021
  • 494 locations
Investigation and Modulation of the Mu-opioid Mechanisms in TMD (in Vivo)

In this study, this team of researchers will investigate the impact of chronic temporomandibular disorder suffering on the endogenous -opioid system in vivo, arguably one of the principal endogenous pain modulatory systems in the brain, and its modulation by 10 daily sessions of primary motor cortex stimulation using high-definition transcranial …

NSAID
pain disorder
chronic pain
new medications
ache
  • 0 views
  • 06 Sep, 2021
  • 1 location
A Pilot Study to Explore the Role of Gut Flora in Rheumatoid Arthritis

This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Rheumatoid Arthritis

rheumatoid arthritis
  • 74 views
  • 12 Sep, 2021
  • 1 location
Impact of Mesenchymal Stem Cells in Knee Osteoarthritis

Many patients with osteoarthritis of the knee fail non-operative measures and elect to have knee arthroplasty to improve their quality of life. If successful, intra-articular mesenchymal stem cell (MSC) injections into the knee may offer another viable non-operative treatment modality. Additionally, this modality may have reparative or regenerative potential, which …

osteoarthritis
knee pain
chronic pain
joint reconstruction
total knee replacement
  • 148 views
  • 18 Sep, 2021
  • 1 location
A Study of Baricitinib in Participants From 1 Year to Less Than 18 Years Old With Juvenile Idiopathic Arthritis

The reason for this study is to see if the study drug baricitinib is safe and effective in the treatment of JIA in participants ages 1 to 17. This study is for participants that have been enrolled in studies I4V-MC-JAHV (NCT03773978) or I4V-MC-JAHU.

arthritis
  • 57 views
  • 12 Sep, 2021
  • 212 locations
Using Virtual Reality to Prevent Pre-operative Anxiety in Ambulatory Surgery Patients

The primary objective is to evaluate the impact on pre-operative anxiety management of using the virtual reality mask for surgery of hallux valgus.

hallux valgus
anxiety
valgus deformity
  • 0 views
  • 08 Sep, 2021
  • 1 location