Musculoskeletal Diseases Clinical Trials

A listing of Musculoskeletal Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 55 clinical trials
A Phase 4, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Bio-naive Participants With Active Psoriatic Arthritis Axial Disease (STAR)

The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) axial disease by assessing reduction in axial symptoms and inflammation.

anti-rheumatic drugs
apremilast
psoriasis
DMARD
NSAID
  • 113 views
  • 24 Oct, 2022
  • 98 locations
Nudging Clinicians to Think Beyond Health in the Norwegian Sickness Absence Clinic. The NSAC Nudge Trial (NSAC)

The Norwegian Sickness Absence Clinic (NSAC) Nudge Study is a naturalistic randomized controlled multicentre trial which aim is to measure the efficacy of nudging clinicians' attention towards patients' motivation for work, barriers for return to work and work environment challenges, on functional recovery as primary outcome, and health outcomes as …

  • 0 views
  • 19 Oct, 2022
  • 5 locations
Multidisciplinary Primary Rehabilitation Care for Patients With Chronic Musculoskeletal Pain (MPRC_CMP)

Rationale: A great variability in treatment contents, ways of collaboration between healthcare professionals, and evaluation methods for the treatment in chronic musculoskeletal pain (CMP), exists. Currently, multidisciplinary diagnostics, pain education and treatment in primary care, in collaboration with secondary care, especially with a biopsychosocial approach, is barely or not organized …

  • 0 views
  • 07 Oct, 2022
  • 5 locations
COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders

This is a randomized, multi-site, adaptive, open-label clinical trial comparing the immune response to different additional doses of COVID-19 vaccine in participants with autoimmune disease requiring immunosuppressive medications. All study participants will have negative serologic or sub-optimal responses (defined as a Roche Elecsys® Anti-SARS-CoV-2 S (RBD) result ≤ 200 U/mL) …

ocrelizumab
autoimmune disease
mycophenolate mofetil
SARS
mycophenolate
  • 79 views
  • 04 Oct, 2022
  • 20 locations
A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study To Evaluate The Efficacy And Safety Of Obinutuzumab In Patients With ISN/RPS 2003 Class III Or IV Lupus Nephritis (REGENCY) (REGENCY)

This study will evaluate the efficacy, safety, and pharmacokinetics of obinutuzumab compared with placebo in patients with International Society of Nephrology/Renal Pathology Society (ISN/RPS) class III or IV lupus nephritis (LN) when added on to standard-of-care therapy consisting of mycophenolate mofetil (MMF) and corticosteroids.

prednisone
mycophenolate
nephritis
kidney biopsy
mammogram
  • 21 views
  • 24 Oct, 2022
  • 99 locations
Comparison of Remimazolam and Dexmedetomidine for Intraoperative Sedation

The purpose of this study is to compare the sedation efficacy of dexmedetomidine and remimazolam for intraoperative sedation during regional block.

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
Prospective Randomized Comparison of Conservative and Opertaive Treatment of Radius Fractures in Elderly Patients

Elderly Patients often suffer from radius fracture. Treatment options are conservative and operative. Aim of the stdy is to find out if there are diffrences in Patient's satisfaction depending on the different treatment. A randomized prospective trial is palnned

  • 0 views
  • 04 Oct, 2022
  • 1 location
Mode of Exercise and Bone Biomarkers in Older Veterans (MOVE)

Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain …

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
Hemodynamic OptimizaTion in Sitting POsition Surgery Trial (HOTSPOT)

Intraoperative hypotension (MAP <65 mmHg) in patients undergoing general anesthesia is a notable risk factor for the development of post-operative complications including acute kidney injury (AKI), myocardial injury, stroke and delirium, and is strongly associated with increased mortality. Moreover, the mean and systolic blood pressure values tend to undergo significant …

  • 0 views
  • 04 Oct, 2022
  • 1 location
Efficacy of Ultrasound-Guided Hydrodissection in Patients With Carpal Tunnel Syndrome

The aim of our study is to determine the effectiveness of US-guided hydrodissection of the median nerve in different contents and volumes in patients diagnosed with mild to moderate carpal tunnel syndrome.

numbness
electrophysiological studies
5% dextrose
  • 0 views
  • 16 Oct, 2022
  • 1 location