Lymphangioleiomyomatosis Clinical Trials

A listing of Lymphangioleiomyomatosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 13 clinical trials
Featured trial
Albuterol in Patients With Lymphangioleiomyomatosis

Background: Lymphangioleiomyomatosis (LAM) is a rare type of lung disease that occurs almost exclusively in women. In LAM, muscle tissue grows in the lungs and starts

lymphangioleiomyomatosis
  • 94 views
  • 22 Dec, 2020
  • 1 location
Effect of Loratadine in Lymphangioleiomyomatosis (LORALAM)

INTRODUCTION: LAM is a rare and lethal disease characterized by progressive cystic lung destruction. Inhibition of mTOR with rapamycin is the current standard of care (SOC), which can slow-down disease. Plasma major histamine metabolite (Methylimidazoleacetic acid [MIAA]) is increased in LAM. Loratadine is a histamine receptor antagonist (HR1), which inhibits …

  • 0 views
  • 23 Mar, 2022
  • 1 location
Nebulized or Inhaled Albuterol for Lymphangioleiomyomatosis

Background Lymphangioleiomyomatosis (LAM) is a rare type of lung disease that occurs almost exclusively in women. In LAM, muscle tissue grows in the lungs and

obstruction
pulmonary disease
lung function tests
lab tests
progressive disease
  • 13 views
  • 10 Aug, 2022
  • 1 location
Multicenter Interventional Lymphangioleiomyomatosis (LAM) Early Disease Trial (MILED)

This is a study to determine if early, long-term low dose sirolimus is effective for preventing progression to more advanced stages.

sirolimus
bronchodilator
chylothorax
vegf-d
vegf
  • 76 views
  • 22 Mar, 2022
  • 4 locations
Feasibility of [11C]Acetate-Positron Emission Tomography (PET) in Lymphangioleiomyomatosis and Tuberous Sclerosis Complex

This study aims to assess [11C]acetate positron emission tomography (PET)/computed tomography (CT) as a biomarker for renal angiomyolipomas and pulmonary lymphangioleiomyomatosis (LAM) and an

  • 0 views
  • 28 Jul, 2022
  • 1 location
Application of 68Ga NEB PET Imaging in the Diagnosis and Evaluation of Lymphatic Disorders

, lymphangioleiomyomatosis, plastic bronchitis, lymphadenopathy caused by rheumatoid arthritis, etc.

  • 0 views
  • 27 Feb, 2022
  • 1 location
Sirolimus for Cowden Syndrome With Colon Polyposis

Colon polyposis (the presence of multiple colon polyps) is very common with Cowden syndrome, as over 60% of patients have 50 or more polyps. In a previous clinical trial, some participants had reduction in the number of colon polyps with the use of the medication sirolimus for a very short …

  • 0 views
  • 30 Nov, 2021
  • 1 location
A National Registry on Chinese Patients With Lymphangioleiomyomatosis

Pulmonary lymphangioleiomyomatosis (LAM), a disease characterized by diffuse cystic changes in the lung, is a rare disorder that affects almost exclusively women. The main objectives of this

  • 4 views
  • 24 Feb, 2022
  • 1 location
Safety and Durability of Sirolimus for Treatment of LAM (MIDAS)

The MIDAS study aims to follow LAM patients who are currently taking, have previously failed or been intolerant of, or may (at some time in the future) take mTOR inhibitors (sirolimus or everolimus) as part of their clinical care. Adult female TSC patients may also enroll, with or without lung …

sirolimus
cystic lung disease
  • 24 views
  • 23 Mar, 2022
  • 8 locations
Study of the Disease Process of Lymphangioleiomyomatosis

Pulmonary lymphangioleiomyomatosis (LAM) is a destructive lung disease typically affecting women of childbearing age. Currently, there is no effective therapy for the disease and the prognosis

x-rays
pulmonary disease
lymphangioleiomyomatosis
chest x-ray
bronchoscopy
  • 4 views
  • 28 Jul, 2022
  • 1 location