Aggressive Fibromatosis Clinical Trials

A listing of Aggressive Fibromatosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 12 clinical trials
A Study of AL102 in Patients With Progressing Desmoid Tumors (RINGSIDE)

The current study is designed to evaluate the efficacy and safety of AL102 in patients with progressive desmoid tumors.

line of therapy
measurable disease
  • 01 Jul, 2022
  • 27 locations
A Safety, Pharmacokinetic and Efficacy Study of a y-Secretase Inhibitor, Nirogacestat (PF-03084014) in Children and Adolescents With Progressive, Surgically Unresectable Desmoid Tumors

This phase II trial studies the side effects and how well nirogacestat works in treating patients patients less than 18 years of age with desmoid tumors that has grown after at least one form of

myocardial infarction
nonsteroidal anti-inflammatory drugs
tumor cells
  • 13 Oct, 2022
  • 51 locations
DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors

>Desmoid tumors Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09/19/2018) Malignant giant cell tumors Chordoma (closed to accrual 11/29/2018)

cancer other
primary tumor
mullerian mixed tumor
free thyroxine
ct scan
  • 22 Oct, 2022
  • 752 locations
Cryotherapy in the Treatment of Desmoid Tumors

Desmoid tumor is a benign neoplasm with an unpredictable course and a high rate of local recurrence if treated surgically. Therefore, over time the surgical approach has become conservative

nonsteroidal anti-inflammatory drugs
hormone therapy
medical therapy
measurable disease
  • 22 Apr, 2022
  • 1 location
A Randomized, Double-blind, Phase Ⅲ Study of Liposomal Doxorubicin in Desmoid Tumor

The aim of this study was to evaluate the efficacy and safety of liposomal doxorubicin in the treatment of desmoid tumors. Unless the subject withdraws from the trial voluntarily, or the

nonsteroidal anti-inflammatory drugs
hormone therapy
metastatic disease
renal function
  • 21 Oct, 2022
  • 1 location
A Phase 1/2 Study of Tegavivint (NSC#826393) in Children, Adolescents, and Young Adults With Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

This phase I/II trial evaluates the highest safe dose, side effects, and possible benefits of tegavivint in treating patients with solid tumors that has come back (recurrent) or does not respond to treatment (refractory). Tegavivint interferes with the binding of beta-catenin to TBL1, which may help stop the growth of …

myelosuppressive chemotherapy
solid tumor
  • 10 Oct, 2022
  • 11 locations
The TNT Protocol: A Phase 2 Study Using Talimogene Laherparepvec,Nivolumab and Trabectedin as First, Second/Third Line Therapy for Advanced Sarcoma, Including Desmoid Tumor and Chordoma (TNT)

This is a Phase 2 study using talimogene laherparepvec, nivolumab, and trabectedin as first, second or third line therapy for advanced sarcoma, including desmoid tumor and chordoma.

kidney function tests
advanced sarcoma
platelet count
metastatic sarcoma
  • 22 Oct, 2022
  • 1 location
Safety and Efficacy Study Using 5-ALA Oral Administration as an Adjuvant Therapy on the Rate of Local Tumor Recurrence in Patients Who Have Desmoids Tumors

therapy on the 3 years rate of local tumor recurrence in patients with desmoid tumors. To evaluate the Safety of 5-ALA administration. 5 years local recurrence rate.

  • 08 Nov, 2020
  • 1 location
HIFU Ablation of Soft Tissue Sarcoma (SarcAblate)

> This study will recruit patients with both resectable and unresectable STS, in addition to unresectable small symptomatic desmoid tumours. 12-16 patients, and a minimum of 10 patients with

cancer chemotherapy
soft tissue sarcoma
  • 21 Mar, 2022
  • 1 location
The Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study

This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.

bone marrow procedure
metastatic disease
langerhans cell histiocytosis
desmoid tumors
  • 13 Oct, 2022
  • 128 locations