Home » Clinical Trials »  Search Clinical Trials

Therapeutic Areas:  |  Endocrinology

Search Medical Condition
Please enter condition
Please choose location from dropdown
Clear Trial Filters

Leiomyomas Clinical Trials

A listing of Leiomyomas medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (9) clinical trials

Efficacy and Safety of Rapamycin (Sirolimus) in the Treatment of Symptomatic Uterine Fibroids and Leiomyomatosis

Recent studies indicate that mTOR pathway is a specific and sensitive tumor target molecule in uterine fibroids, which can be used as a target molecule for interventional therapy and can provide a new cut-in point for nonoperative treatment. However, the application of mTOR inhibitor (sirolimus) in the treatment of uterine ...

Phase

Aromatase Plus GnRH Analogue Versus Ulippristal Acetate in Uterine Fibroids

Recently it has been introduced the Ulipristal acetate as medical treatment for symptomatic uterine fibroid. The investigators used in the past for the treatment of other benign gynecological diseases such as endometriosis and adenomyosis a combined therapy with Aromatase inhibitor plus GnRH analog. The investigators also used this combined treatment ...

Phase

Ulipristal Acetate Versus GnRH Analogue Treatment Before Hysteroscopic Resection of Uterine Leiomyoma

The uterine leiomyoma is the most common benign tumor of the female genital tract. The myomas are usually clinically apparent in 25% of patients. Submucosal fibroid are about 10% of all uterine myoma; they distort the endometrial cavity causing heavy and/or irregular bleeding (AUB) and infertility. According to the degree ...

Phase

Ulipristal Acetate for the Preoperative Management of Hypoechoic Cellular Leiomyomas

Rationale why study should be conducted: Leiomyomas are the most common benign neoplasm in women; it has been estimated that these tumors occur in at least 25% of all women, which is probably an underestimation, because this figure is based on a select population. They are histologically composed by smooth ...

Phase

Ulipristal Acetate Versus GnRH Analogue and Myometrial Preservation

Uterine leiomyoma is the most common benign tumor of the female genital tract. Submucosal fibroid are about 10% of all uterine myoma. They grow inside the uterine cavity and are usually associated with menorrhagia, abnormal uterine bleeding (AUB) and infertility. According to the degree of myometrial penetration, the European Society ...

Phase

Ulipristal vs. GnRHa Prior to Laparoscopic Myomectomy

Rationale: Laparoscopic myomectomy is increasingly performed over laparotomic myomectomy, because of the many benefits for the patient in terms of pain, hospital stay and recovery. In order to increase the success rate of a laparoscopic procedure pre-treatment to decrease the volume might be beneficial. Gonadotropin-releasing hormone agonists (GnRHa) are used ...

Phase

Misoprostol for Reduction of Blood Loss During Fibroid Surgery

This is a trial of women undergoing fibroid surgery at a university-affiliated tertiary care center. Eligible participants will be randomized to receive preoperative 400ucg buccal (under the tongue) misoprostol or placebo on the basis of total fibroid volume, location, parity. Intra-operative blood loss will be compared between groups.

Phase

Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids

Uterine fibroids are common and debilitating problem for some women. Nearly 60% of women with fibroids report that symptoms affect their quality of life and impede physical activity, and 24% report that fibroid symptoms prevent them from reaching their true potential at work. Heavy menstrual bleeding, the most common symptom ...

Phase

Mechanistic Characterization of Uterine Pain

Due to a lack of noninvasive tools to study uterine physiology, the root causes of menstrual cramping pain within primary dysmenorrhea and secondary dysmenorrhea (leiomyoma, endometriosis, adenomyosis) remain unknown. This pain does not respond to typical over-the-counter anti-inflammatories in 15% of women and is a leading risk factor for developing ...

Phase