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Telomeres Clinical Trials

A listing of Telomeres medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (9) clinical trials

DNA is a structure in the body. It contains data about how the body develops and works. Telomeres are found on the end of chromosomes in DNA. Some people with short telomeres or other gene changes can develop diseases of the bone marrow, lung, and liver. Researchers want to see ...

Phase

Genetic and Telomere Characteristics of High of Grade Soft Tissue Sarcomas

Aims The investigators plan a 2 year pilot observational study to: Identify and quantify circulating cell-fee DNA (cfDNA) in cases of Soft Tissue Sarcoma (STS) Investigate Telomere Maintenance Mechanisms (TMM) in STSs. Use TMM associated genetic mutations to identify and quantify tumour-derived cfDNA in STSs at time of tumour resection ...

Phase N/A

The Association Between Telomere Length and Propofol Dose in Anesthesia-induction

A hundred patients with the American Society of Anesthesiologists (ASA) physical status I-II, aged from 18 to 80 years, gave an informed-written consent to participate.Testing took place in the morning after an overnight fast. Patients were scheduled for elective surgical procedures. After arrival to the operating theater, the peripheral venous ...

Phase N/A

Consequences of DNA Repair and Telomere Defects on the Function of the Immune System: Application to CVID and Immune Deficiencies With Dysmorphic Syndromes

The molecular mechanisms participating in the various aspects of the DNA Damage Response (DDR) are absolutely essential to maintain the genome dynamics essential to all living organisms. The most commonly studied consequence of faulty DDR is genome instability participating in cancer onset. In the present proposal, we wish to explore ...

Phase N/A

Telomeres and Arterial Aging

Specific objectives: To determine whether TL during early development, which is primarily reflected in muscle TL, and LTL attrition during development, which is primarily expressed in the difference between muscle TL and LTL, are associated with indices of arterial aging. To examine the relation between EPC-TL to endothelial regenerative capacity ...

Phase N/A

Lifestyle Change for Better Health

The goal of the research is to provide a first critical test of the novel scientific idea that a combined diet and exercise intervention may ameliorate shortening of leukocyte telomere length (LTL) in individuals with histories of successfully treated non-metastatic bladder cancer (BC) or colorectal adenoma (CRA) compared to a ...

Phase N/A

Low-Dose Danazol for the Treatment of Telomere Related Diseases

Telomere disease is caused by accelerated telomere attrition and results in multi-organ dysfunction. Telomeres are nucleotide repeats of non-coding DNA at the end of the chromosomes which function as protective caps to prevent erosion of genomic DNA during cell division and to protect chromosomes from recognition as single stranded DNA. ...

Phase

Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery

To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length

Phase N/A

Telomere Associated Variables (TAVs) in Prostate Cancer

In this study, patient inclusion and sample collection are multicentric. Sample analysis will be carried out at Life Length's laboratories at the Madrid Science Park in Canto Blanco university campus. The study will be initiated immediately after approval by the IRB and has an overall length of 12 months (recruiting ...

Phase N/A