Metastatic Castration Resistant Prostate Cancer

Inclusion Criteria:

• Are a male or female at least 18 years of age
• Have histologically or cytologically confirmed adenocarcinoma of the prostate
• Have metastatic prostate cancer disease
• Are surgically or medically castrated
• Have had no prior treatment with cytotoxic chemotherapy
• Demonstrate adequate organ function

Exclusion Criteria:

• Have known symptomatic brain metastases.
• Have clinically significant cardiovascular disease
• Have untreated or impending spinal cord compression
• Have a severe concurrent disease, infection, or comorbidity
• Have a history of seizure
• Have had major surgery within 4 weeks
• Have known immunodeficiency virus (HIV) infection, hepatitis B or C