Using Connectomics to Characterize Risk for Alzheimer's Disease

Phase

N/A

Condition

Mild Cognitive Impairment

Alzheimer's Disease

Dementia

Treatment

N/A

Clinical Study ID

TX249207

Pro00071249

Ages 45-85
All Genders
Accepts Healthy Volunteers

Study Summary

This study is looking for people over the age of 45 who have Alzheimer’s, mild cognitive impairment, or memory problems. The study is also looking for people with normal cognition, as a comparison. The study is interested in the ways that brain scans may change over time.

Eligibility Criteria

Inclusion

You could be eligible for this study if:
-You are between the ages of 45 and 85.
-You have a ‘study partner’—a family member, friend, or caregiver—who would be willing to accompany you on all study visits.
You either:
-Have Alzheimer’s, mild cognitive impairment, or memory loss; or
-Are cognitively normal.

You may not be eligible for this study if:
-You cannot have an MRI scan, for example because of metal in your body.
-You are currently taking an experimental medication.
-You are undergoing chemotherapy.
-You are pregnant.

Study Design

Study Description

Study schedule:
-You will have 4 or 5 study visits. Each visit will take 1-3 hours.
At the start of the study:
-You will give a sample of blood.
-You will do cognitive testing.
-You will have brain scans (described below).
At the end of the study:
-You will repeat some or all of the study-start activities.
The study will take about a year.

Study activities may include:
-Having a sample of blood taken from your arm vein, using a needle.
-Doing cognitive testing, which may be in the form of interview-style conversations, paper-and pencil questionnaires, computer tests, and/or other activities.
-Doing brain scans (described below).
-Having an injection as a standard part of the brain scan procedure.

Treatment or experiment details:
-One of the brain scans is an MRI. For this, you will lie inside the scanning machine for about an hour while it takes a 3D image of your brain.
-The other brain scan is a PET scan. For this, you will have an injection in your arm vein. Then, you will lie inside the scanning machine for about an hour while it takes a 3D image of your brain.
-The study is interested in the way that connections in the brain change over time in people with Alzheimer’s vs. during healthy aging.
-There is no treatment or experiment being tested in this study.

Connect with a study center

Medical University of South Carolina
Charleston, South Carolina 29425
United States
Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.