Genotypic Influences on Network Progression in Parkinson's Disease

Last updated: February 1, 2022
Sponsor: N/A
Overall Status: Active - Recruiting

Phase

N/A

Condition

Parkinson's Disease

Treatment

N/A

Clinical Study ID

TX224549
  • Ages 40-75
  • All Genders

Study Summary

The goal of this research study is to help scientists better understand how mutations in the GBA (glucocerebrosidase beta acid) gene affects patients with Parkinson’s disease. Mutations in the GBA gene are the most common genetic risk factors for Parkinson's, affecting about 10 percent of the more than 6 million people estimated to have the disease.

Through prior research studies we have found patterns of brain activity that are common among patients with Parkinson’s disease (PD). This study will continue to investigate these patterns in patients with PD with a GBA mutation and patients with PD without the GBA mutation. We hope that this information will one day improve treatment for the disease.

Eligibility Criteria

Inclusion

Inclusion:

  1. Diagnosis of PD made according to UK Parkinson’s Disease Society Brain Bank Criteria;
  2. Ability to provide written informed consent;
  3. Age 40-75;
  4. Stable dose of antiparkinsonian medication for >1 month prior to study entry.

Exclusion:

  1. Subjects with pathogenic mutations in LRRK2;
  2. History of known causative factors such as encephalitis or neuroleptic treatment;
  3. Patients with dementia (defined as a Mini-Mental Status Exam score <24 or a Telephone Interview for Cognitive Status score <26);
  4. Atypical parkinsonian features including myoclonus, apraxia, oculomotor abnormalities, incontinence, ataxia, sensory loss, or pyramidal signs;
  5. Known structural brain lesions;
  6. Patients with a history of stroke, head injury, high intracranial pressure or severe headaches;
  7. Psychiatric disorder, including a history of major depression in the past 36 months;
  8. Pregnant or breastfeeding women (female subjects of child-bearing potential will be screened for pregnancy before imaging).

Study Design

Study Start date:
Estimated Completion Date:

Study Description

Connect with a study center

  • Northwell Office of Clinical Research

    Lake Success, New York 11042
    United States

    Active - Recruiting

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