AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

Last updated: June 1, 2026
Sponsor: Novo Nordisk A/S
Overall Status: Active - Recruiting

Phase

3

Condition

Obesity

Diabetes Prevention

Treatment

Placebo (matched to NNC0487-0111)

NNC0487-0111

Clinical Study ID

NCT07503210
NN9490-8559
2025-523804-62
U1111-1327-1477
  • Ages > 18
  • All Genders

Study Summary

The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Male or female (sex at birth).

  • Age 18 years or above at the time of signing the informed consent.

Exclusion

Exclusion Criteria:

  • Glycated haemoglobin (HbA1c) greater than or equal to ≥ 6.5% [48 millimoles per mole (mmol/mol)] as measured by the central laboratory at screening.

  • History of type 1 or type 2 diabetes mellitus as declared by the participant orreported in the medical records.

  • Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP 1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), oramylin analogues before screening.

Study Design

Total Participants: 600
Treatment Group(s): 2
Primary Treatment: Placebo (matched to NNC0487-0111)
Phase: 3
Study Start date:
April 21, 2026
Estimated Completion Date:
July 04, 2028

Connect with a study center

  • Conexa

    Ciudad Autonoma de Buenos Aires, Buenos Aires C1018ADE
    Argentina

    Active - Recruiting

  • CICEMO- Consultorio (Av Directorio)

    Ciudad Autónoma de Buenos Aires, Buenos Aires C1424CIQ
    Argentina

    Active - Recruiting

  • Instituto de Investigaciones Clinicas Mar Del Plata

    Mar del Plata, Buenos Aires B7600FZN
    Argentina

    Active - Recruiting

  • CIPREC Pueyrredon

    Buenos Aires, C1119ACN
    Argentina

    Active - Recruiting

  • Sydney Clinical Trials

    Campbelltown, New South Wales 2560
    Australia

    Active - Recruiting

  • Sydney Cardiometabolic Centre

    Liverpool, New South Wales 2170
    Australia

    Active - Recruiting

  • Hunter Diabetes Centre

    Merewether, New South Wales 2291
    Australia

    Active - Recruiting

  • Nightingale Research

    Adelaide, South Australia 5000
    Australia

    Active - Recruiting

  • Anima Research Center

    Diepenbeek, 3590
    Belgium

    Active - Recruiting

  • AZ Groeninge - Kortrijk - Centrum Endo - Diabetologie

    Kortrijk, 8500
    Belgium

    Active - Recruiting

  • Centre hospitalier universitaire de Liège (CHU de Liège)

    Liège, 4000
    Belgium

    Site Not Available

  • AZ OOSTENDE (Campus DAMIAAN)

    Ostend, 8400
    Belgium

    Site Not Available

  • DCC 1 - Lom EOOD

    Lom, 3600
    Bulgaria

    Active - Recruiting

  • AIPSOMCEMD ENDO MED CONSULT 2020 - Dr. Aleksander Botushanov EOOD

    Plovdiv, 4002
    Bulgaria

    Active - Recruiting

  • MHAT Med Line Clinic

    Plovdiv, 4000
    Bulgaria

    Active - Recruiting

  • UMHAT Kaspela EOOD, Endocrinology and Metabolic Diseases Clinic

    Plovdiv, 4001
    Bulgaria

    Active - Recruiting

  • AIPSMC Dr. Traykovska EOOD

    Sofia, 1839
    Bulgaria

    Active - Recruiting

  • Medical Center Maraya Med EOOD

    Sofia, 1756
    Bulgaria

    Active - Recruiting

  • SGHAT Dr. Shterev EOOD

    Sofia, 1330
    Bulgaria

    Active - Recruiting

  • UMHAT Aleksandrovska EAD, Clinic of Endocrinology and Metabolic Diseases

    Sofia, 1431
    Bulgaria

    Active - Recruiting

  • Sjællands Universitetshospital, Køge - Medicinsk Afdeling

    Køge, Region Sjælland 4600
    Denmark

    Active - Recruiting

  • Sydvestjysk Sygehus Esbjerg - Medicinsk Endokrinologisk Ambulatorium, Forskningsenheden

    Esbjerg, Region Syddanmark 6700
    Denmark

    Active - Recruiting

  • Sanos Clinic - Vejle

    Vejle, Region Syddanmark 7100
    Denmark

    Active - Recruiting

  • CHU DE CLERMONT-FERRAND-HOPITAL GABRIEL MONTPIED_Service de Nutrition

    Clermont-Ferrand, 63000
    France

    Active - Recruiting

  • CHU GRENOBLE ALPES-SITE NORD MICHALLON_Endocrinologie,diabétologie,maladies de la nutrition

    La Tronche, 38700
    France

    Active - Recruiting

  • GROUPE SOS SANTE-HOPITAL LE CREUSOT-HOTEL DIEU_ Service de Diabétologie

    Le Creusot, 71200
    France

    Active - Recruiting

  • CHU LILLE-HOPITAL CLAUDE HURIEZ_Service de Chirurgie Générale et Endocrinienne

    Lille, 59000
    France

    Active - Recruiting

  • CHU DE POITIERS_Centre d'investigation Clinique

    Poitiers, 86000
    France

    Active - Recruiting

  • Diabetologikum - Diabetologische Schwerpunktpraxis Dr. Thomas Segiet

    Speyer, LÄK Rheinland-Pfalz 67346
    Germany

    Active - Recruiting

  • Wendisch - Dahl Hamburg - DZHW

    Hamburg, 22607
    Germany

    Active - Recruiting

  • Prof. Dr. Schiefke Ingolf, EUGASTRO GmbH

    Leipzig, 04103
    Germany

    Active - Recruiting

  • Diabetologische Gemeinschaftspraxis Dr. Staudenmeyer und Dr. Schiwietz

    Lingen, 49808
    Germany

    Active - Recruiting

  • Institut für Diabetesforschung GmbH Münster - Dr. med. Rose

    Münster, 48145
    Germany

    Active - Recruiting

  • RED-Institut für medizinische Forschung und Fortbildung GmbH

    Oldenburg in Holstein, 23758
    Germany

    Active - Recruiting

  • Zentrum für klinische Studien Alexander Segner

    Saint Ingbert-Oberwürzbach, 66386
    Germany

    Active - Recruiting

  • Arcispedale Sant'Anna (Cona) - UO di Endocrinologia

    Ferrara, Emilia-Romagna 44124
    Italy

    Site Not Available

  • IRCCS Ospedale Policlinico San Martino - Medicina Interna e Specialità Mediche

    Genoa, Liguria 16132
    Italy

    Active - Recruiting

  • Fondazione Salvatore Maugeri I.R.C.C.S. - Pavia - Dipartimento Medicina Interna e Generale

    Pavia, Lombardy 27100
    Italy

    Active - Recruiting

  • Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone - Presidio Villa Belmonte

    Palermo, Sicily 90127
    Italy

    Active - Recruiting

  • Azienda Ospedaliera di Padova - UOSD Chirurgia Bariatrica

    Padova, Veneto 35128
    Italy

    Site Not Available

  • Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Civile Maggiore Borgo Trento - U.O. Geriatria

    Verona, Veneto 37126
    Italy

    Active - Recruiting

  • A.O.Universitaria S.ORSOLA-MALPIGHI - U.O.Endocrinologia e Cura

    Bologna, 40138
    Italy

    Active - Recruiting

  • IRCCS Humanitas - U.O. Endocrinologia e Diabetologia

    Rozzano (MI), 20089
    Italy

    Active - Recruiting

  • PreCare Trial & Recruitment

    Born, Limburg 6121 XK
    Netherlands

    Active - Recruiting

  • Progress Clinical Research Den Bosch

    's-Hertogenbosch, North Brabant 5223 LA
    Netherlands

    Active - Recruiting

  • EB Flevo Research BV

    Almere Stad, 1311RL
    Netherlands

    Active - Recruiting

  • Meander MC

    Amersfoort, 3813 TZ
    Netherlands

    Site Not Available

  • Rijnstate Ziekenhuis

    Arnhem, 6815 AD
    Netherlands

    Active - Recruiting

  • Centro Periferico De Especialidades Bola Azul

    Almería, 04009
    Spain

    Active - Recruiting

  • Hospital Clinic i Provincial

    Barcelona, 08036
    Spain

    Active - Recruiting

  • H. de León_Endocrinología

    León, 24008
    Spain

    Site Not Available

  • Hospital Clínico San Carlos

    Madrid, 28040
    Spain

    Active - Recruiting

  • H. Clinico Univ. Virgen de la Victoria

    Málaga, 29010
    Spain

    Active - Recruiting

  • H.U. Quirónsalud Madrid

    Pozuelo de Alarcón, 28223
    Spain

    Active - Recruiting

  • Hospital Universitario Virgen del Rocío

    Seville, 41013
    Spain

    Active - Recruiting

  • EMS Healthcare

    Cheshire, CH65 4LE
    United Kingdom

    Active - Recruiting

  • Clifton Medical Centre

    Rotherham, S65 1DA
    United Kingdom

    Active - Recruiting

  • Staploe Medical Centre

    Soham, CB7 5JD
    United Kingdom

    Active - Recruiting

  • Albany House Medical Centre

    Wellingborough, NN8 4RW
    United Kingdom

    Active - Recruiting

  • Pinnacle Research Group LLC

    Anniston, Alabama 36207
    United States

    Active - Recruiting

  • Diablo Clinical Research, Inc.

    Walnut Creek, California 94598
    United States

    Active - Recruiting

  • Florida Inst For Clin Res LLC

    Orlando, Florida 32825
    United States

    Active - Recruiting

  • Endeavor Health

    Skokie, Illinois 60077
    United States

    Site Not Available

  • Midwest Inst For Clin Res

    Indianapolis, Indiana 46260
    United States

    Active - Recruiting

  • Medication Mgmnt, LLC_Grnsboro

    Greensboro, North Carolina 27405
    United States

    Active - Recruiting

  • PMG Research of Wilmington LLC

    Wilmington, North Carolina 28401
    United States

    Active - Recruiting

  • UPA Ctr Weight and Eating Dis

    Philadelphia, Pennsylvania 19104
    United States

    Active - Recruiting

  • Clinical Res Collaborative

    Cumberland, Rhode Island 02864
    United States

    Active - Recruiting

  • North Texas Endocrine Center

    Dallas, Texas 75231
    United States

    Site Not Available

  • UT Southwestern Med Cntr

    Dallas, Texas 75390-9302
    United States

    Active - Recruiting

  • Selma Medical Associates

    Winchester, Virginia 22601-3834
    United States

    Active - Recruiting

  • Rainier Clin Res Ctr Inc

    Renton, Washington 98057
    United States

    Active - Recruiting

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.