Early Myocardial Dysfunction Helps Identify Severe Refractory Pediatric Lupus

Phase

N/A

Condition

Lupus

Systemic Lupus Erythematosus

Cutaneous Lupus Erythematosus

Treatment

N/A

Clinical Study ID

NCT07425730

ELYZX202102

Ages 7-17
All Genders
Accepts Healthy Volunteers

Study Summary

To investigate biomarkers to identify pediatric SR-SLE patients by non-invasive echocardiographic techniques.

Eligibility Criteria

Inclusion

Inclusion Criteria:

fulfill the American College of Rheumatology (ACR) criteria
disease onset at ages before 18 years

Exclusion

Exclusion Criteria:

patients with a history of concomitant malignancy
patients with active bacterial, viral, fungal, mycobacterial infection

Study Design

February 01, 2026

July 01, 2026

Study Description

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Although therapeutic advances have improved outcomes, a significant subset remains with severe disease activity despite optimal therapy, which is recognized as the severe refractory SLE (SR-SLE).A recent study using advanced echocardiographic techniques of global longitudinal strain (GLS) have revealed that left ventricular dysfunction is common in SLE patients and correlates with disease severity.The finding underscores the potential role of early myocardial dysfunction as a phenotypic marker of SR-SLE.To our knowledge, there are no validated biomarkers to reliably identify patients with SR-SLE at an early stage, especially in the pediatric population. Therefore, this study aimed to investigate biomarkers to identify pediatric SR-SLE patients.

Connect with a study center

Shanghai Children's Medical Center
Shanghai 1796236, Shanghai Municipality 1796231 200127
China
Active - Recruiting

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