Steroid Use in Treatment of Allergic Reactions to Food

Last updated: January 26, 2026
Sponsor: Johannes Trueck
Overall Status: Active - Recruiting

Phase

4

Condition

Allergy (Pediatric)

Allergy

Allergies & Asthma

Treatment

Systemic corticosteroids

Antihistamines

Adrenaline (rescue medication)

Clinical Study ID

NCT07341776
BASEC-2025-00320
SNCTP000006696
HumRes67580
  • Ages 6-18
  • All Genders

Study Summary

In this study, the investigators want to find out whether a specific medication commonly used for severe allergic reactions is really necessary. When children have allergic reactions to foods, they are often given medications to relieve the symptoms. In addition to adrenaline and antihistamines, steroids are frequently administered in German-speaking Switzerland. However, it is unclear whether steroids are really helpful in this situation. To investigate this, the investigators are comparing two groups: one group receives additional steroids, and the other does not. Which treatment a participant receives is decided randomly, like flipping a coin. The study takes place during a pre-scheduled provocation test at the clinic. If an allergic reaction occurs, the usual emergency medications will be administered. Doctors will closely monitor how the reaction develops. No additional tests or visits are required. The results of this study could help improve allergy treatment in the future.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • suspected or confirmed IgE-mediated food allergy

Exclusion

Exclusion Criteria:

  • Non-IgE mediated food allergies

  • Non-food allergies

  • Age outside the specified range

  • Contraindications for an oral food challenge or oral steroid use within one weekbefore the challenge.

Study Design

Total Participants: 160
Treatment Group(s): 3
Primary Treatment: Systemic corticosteroids
Phase: 4
Study Start date:
January 26, 2026
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • University Children's Hospital Basel

    Basel 2661604, Basel 4031
    Switzerland

    Active - Recruiting

  • University Children's Hospital, Zürich

    Zurich 2657896, Canton of Zurich 2657895 8008
    Switzerland

    Active - Recruiting

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