Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) in Gastric Cancer

Last updated: January 10, 2026
Sponsor: Ukrainian Society of Clinical Oncology
Overall Status: Active - Recruiting

Phase

N/A

Condition

Ulcers

Gastric Ulcers

Gastric Cancer

Treatment

curative-intent surgery + HIPEC

Clinical Study ID

NCT07313579
24999/2025
  • Ages 18-80
  • All Genders

Study Summary

The study investigates the outcomes of hyperthermic intraperitoneal chemoperfusion (HIPEC) in combination with curative-intent gastrectomy in resectable locally-advanced and limited-metastatic (low peritoneal cancer index) gastric cancer.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age 18-80

  2. Hystologicaly proven gastric adenocarcinoma

  3. ECOG status 0-1

  4. Written consent to participate in the study

  5. Medically and technically operable gastric tumor

  6. Only T4a or T4b tumours with any peritoneal cytology status

  7. Cytologically positive peritoneal washings (cyt+) with any T and N criteria

  8. Adequate haemopoetic, renal and hepatic function (Hb > 120, PLT > 150*10^9/l, ALT < 60, AST <40, total bilirubin < 21 µmol/l, Creatinine clearance (male - 90-140,female - 80-130 ml/min)

Exclusion

Exclusion Criteria:

  1. Pregnancy/breastfeeding

  2. ECOG status 2-4

  3. Concomitant malignancy

  4. Mitomycin and/or Cisplatin hypersensitivity

  5. Uncontrollable chronic diseases

  6. Patients with coexisting malignancy other than basal cell carcinoma of the skinwithin the last five years.

  7. Presence of metastases other than regional or peritoneal (such as liver, lungs,bone, brain, distant lymph nodes)

  8. History of allergic reactions associated with cisplatin and Mitomycin C

  9. Patients with psychiatric illness/social situations with impaired compliance

  10. •Refusal to participate

Study Design

Total Participants: 200
Treatment Group(s): 1
Primary Treatment: curative-intent surgery + HIPEC
Phase:
Study Start date:
December 01, 2025
Estimated Completion Date:
December 01, 2035

Study Description

Several recent studies showed that near-perfect curative-intent R0 surgical technique combined with systemic chemotherapy or even immunotherapy may not always be enough to eliminate microscopic deposits or eliminate peritoneal dissemination in locally advanced gastric cancer or low peritoneal cancer-index (PCI) tumors. The risk of peritoneal dissemination is especially high for T4 tumors, for those with cytologically positive peritoneal washings. Moreover, the risk of peritoneal relapse in low PCI tumors is remarkably high. Combination of surgery and intraperitoneal chemotherapy aims to minimise the risks of the aforementioned peritoneal progression. In the study investigators perform curative surgery followed by single dose of hyperthermic intraperitoneal chemotherapy (HIPEC).

Connect with a study center

  • National Cancer Institute (NCI)

    Kyiv 703448,
    Ukraine

    Active - Recruiting

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