Taldefgrobep Alfa in Adults With Overweight and Obesity

Key Inclusion Criteria:

1. a. BMI > 30 kg/m2 and BMI < 42 kg/m2, OR b. BMI ≥ 27 kg/m2 and BMI <30 kg/m2 with atleast one weight-related co-morbidity

2. History of at least one self-reported unsuccessful dietary effort to lose bodyweight.

3. Stable body weight and stable physical activity within 3 months prior to screeningper participant self-report.

4. All participants must adhere to protocol contraception requirements

Key Exclusion Criteria:

1. History of diabetes, including individuals with a HbA1c of ≥ 6.5% at Screening

2. Non-ambulatory participants, defined as unable to take at least 10 stepsindependently.

3. Females currently pregnant or breastfeeding, or who intend to become pregnant or tobreastfeed.

4. Participation in another investigational clinical trial while participating in thisclinical trial