A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia

Inclusion Criteria:

• History of fasting triglyceride levels of ≥500 milligrams per deciliter (mg/dL),based on medical history

• Fasting triglyceride level ≥500 mg/dL at two separate visits during screening (atleast 7 days apart)

• Have a body mass index (BMI) within the range of 18.5 to 45.0 kilograms per squaremeter (kg/m2) (inclusive)

Exclusion Criteria:

• Have had a major atherosclerotic cardiovascular event within the past 3 months priorto screening

• Have a history of acute pancreatitis within 12 months prior to screening

• Have a known genetically confirmed diagnosis of Familial Chylomicronemia Syndrome

• Have a history of or planned treatment involving any gene editing or gene therapymodalities, including but not limited to CRISPR-based, viral vector-mediated, orother genetic modification techniques

• Have a history of chronic alcohol abuse within 3 years prior to screening