The Impact of Irrisept in Reducing Urinary Tract Infection During Urethral Catheter Removal.

Last updated: November 16, 2025
Sponsor: Ohio State University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Urinary Incontinence

Bladder Disorders

Urinary Tract Infections

Treatment

Normal Saline

0.05% Chlorhexidine Gluconate

Clinical Study ID

NCT07239219
STUDY20250670
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Given the high burden of post-catheter removal UTIs, this study aims to evaluate Irrisept instillation as a non-antibiotic intervention to reduce infection rates. By comparing Irrisept to saline irrigation, the study will provide critical insights into the efficacy of antiseptic bladder irrigation in preventing UTIs while minimizing antibiotic use. If successful, this approach could lead to new clinical guidelines for catheter removal protocols, improving patient outcomes and reducing healthcare costs.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Presenting to the urology clinic for catheter removal

  2. Must be 18 years or older.

  3. The patient must be able to understand and willing to provide informed consent asdescribed in this study protocol.

  4. Must be willing to complete a post-catheter removal survey

Exclusion

Exclusion Criteria:

  1. Allergy or adverse reaction to chlorohexidine gluconate

  2. Under the age of 18

  3. Refuse to provide informed consent

  4. On antibiotic therapy for any indication.

  5. Women who are pregnant or breastfeeding

  6. Signs of skin or systemic infection

  7. Patients undergoing catheter exchange

Study Design

Total Participants: 300
Treatment Group(s): 2
Primary Treatment: Normal Saline
Phase:
Study Start date:
December 31, 2025
Estimated Completion Date:
January 01, 2028

Connect with a study center

  • The Ohio State University

    Columbus 4509177, Ohio 5165418 43212-3153
    United States

    Active - Recruiting

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