A Study of LY3549492 in Healthy Participants and Participants With Overweight or Obesity

Inclusion Criteria:

• Have a hemoglobin A1c level of less than 6.5 percent (%) at screening.

• Have a body mass index (BMI) of 25.0 to 45.0 kilogram per square meter (kg/m²),inclusive, at screening

• Participants assigned male at birth (AMAB) or participants assigned female at birth (AFAB) who are individual of childbearing potential (INOCBP) Contraceptive use byparticipants should be consistent with local regulations regarding the methods ofcontraception for those participating in clinical studies.

Exclusion Criteria:

• Have obesity induced by endocrine disorders such as Cushing's syndrome or PraderWilli syndrome.

• Have any of the following conditions at screening,

• supine systolic blood pressure of 160 millimeter of mercury (mmHg) or greater

• supine diastolic blood pressure of 100 mmHg or greater, or

• resting pulse rate of greater than 95 beats per minute (bpm) or less than 45bpm. (Note: white-coat hypertension is excluded; therefore, if a repeatedmeasurement of blood pressure after at least 5 minutes shows values within therange, the participant can be included).

• Have had any of the following within 6-months prior to screening

• myocardial infarction

• unstable angina

• coronary artery bypass graft

• percutaneous coronary intervention. (Note: diagnostic angiograms are permitted)

• transient ischemic attack

• cerebrovascular accident or decompensated congestive heart failure, or

• New York Health Association Class III or IV heart failure.

• Have serum triglyceride of 5 millimoles per liter (mmol/L) or greater (442milligrams per deciliter [mg/dL]) at screening

• Have had any exposure to glucagon-like peptide-1 (GLP-1) analogs or other relatedcompounds within the 3 months prior to screening