A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight

Inclusion Criteria:

• Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher atscreening

• Have a diagnosis of stress urinary incontinence

Exclusion Criteria:

• Have had urinary incontinence surgery

• Have recently received onabotulinumtoxin A (Botox) bladder injections or currentlytaking medications for urinary incontinence

• Have given birth within one year of screening

• Have had a change in body weight of more than 11 pounds within 90 days prior toscreening

• Have used any anti-obesity medication or alternative weight loss remedies within 180days prior to screening

• Have type 1 diabetes, type 2 diabetes, or any other type of diabetes

• Have had a cardiovascular health condition within 90 days prior to screening

• Are pregnant, intending to be pregnant, breastfeeding, or intending to breastfeedfor the duration of the study