A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)

Inclusion Criteria:

The main inclusion criteria include but are not limited to the following:

• Has a clinical diagnosis of axial spondyloarthritis (axSpA) and meets the Assessmentof SpondyloArthritis international Society (ASAS) classification criteria for axSpAincluding ≥3 months of back pain with age at symptom onset <45 years

• Meets the radiographic criterion of the modified New York criteria for ankylosingspondylitis (AS) as determined by central reading at Screening

• Has active disease at Screening and Randomization

• Has a history of inadequate response (IR)/intolerance to nonsteroidalanti-inflammatory drugs (NSAIDs) and is biologic disease-modifying antirheumaticdrug (bDMARD)-naive, or has a history of IR/intolerance to up to a maximum of 2bDMARD classes

Exclusion Criteria:

The main exclusion criteria include but are not limited to the following:

• Has any arthritis with onset before age 17 years or current diagnosis ofinflammatory joint disease other than radiographic axial spondyloarthritis (r-axSpA) (such as, but not limited to, rheumatoid arthritis, systemic lupus erythematosus,psoriatic arthritis (PsA), systemic sclerosis, myositis, etc.), or any otherconditions that may, in the judgment of the investigator, interfere with theassessment of r-axSpA

• Has a history of cancer (except fully treated non-melanoma skin cancers or cervicalcarcinoma in situ after complete surgical removal) within the last 5 years

• Has any active infection

• Has known allergies, hypersensitivity, or intolerance to tulisokibart or itsexcipients