TLN-121 in Relapsed or Refractory Non-Hodgkin Lymphomas

Inclusion Criteria:

Disease Characteristics

1. Participant must have measurable disease at study entry

2. Participants must have one of the following histologically documented hematologicmalignancies:

3. Diffuse large B-cell lymphoma (DLBCL), not otherwise specified (DLBCL, NOS),Follicular lymphoma (FL) grade 3b, or transformed lymphoma from FL following atleast 2 prior lines of therapy.

4. FL grade 1-3a that requires treatment following at least 2 prior lines oftherapy.

5. The following Peripheral T-cell lymphoma (PTCL) subtypes that have relapsedafter, or not responded to at least 1 prior systemic treatment regimen:

• Nodal T-follicular helper (Tfh) cell lymphoma angioimmunoblastic;Follicular helper T-cell lymphoma, angioimmunoblastic type (AITL).
• Nodal Tfh cell lymphoma, follicular type; Follicular helper T-celllymphoma, follicular type.
• Nodal Tfh cell lymphoma, NOS; Follicular helper T-cell lymphoma, NOS.

3. High-Grade B-Cell Lymphoma that has relapsed after, or not responded to at least 2prior systemic treatment regimens.

4. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

Exclusion Criteria:

1. Participants must not have current central nervous system (CNS) involvement.Participants with past history of CNS involvement of lymphoma must have had CNSdisease fully treated with no evidence of recurrence within 12 months.

2. Participant must not have a history of autologous stem cell transplantation within 60 days or allogeneic stem cell transplantation within 90 days prior to the start ofthe study.

3. Participant must not have a history of CAR T-cell or other T-cell targetingtreatment ≤ 4 weeks prior to the start of the study.

4. Participant must not have major surgery or severe trauma within 4 weeks prior to thestart of the study.

5. Participants must not have any condition, including significant acute or chronicmedical illness, active or uncontrolled infection, or the presence of laboratoryabnormalities, that places participants at unacceptable risk if participating inthis study.

6. Pregnant or lactating.

7. Conditions that could affect drug absorption.