A Study Evaluating the Effect of Daily Oral RO7795081 in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity

Inclusion Criteria:

• Participants must have at screening:

1. Body mass index (BMI) greater than or equal to (≥)30.0 kg/m^2; or

2. BMI ≥27.0 kg/m^2 and <30.0 kg/m^2 with at least one weight-related comorbidity,such as hypertension, dyslipidemia, diagnosis of obstructive sleep apnea,cardiovascular disease

• History of ≥1 self-reported unsuccessful diet/exercise effort to lose body weight

• A stable body weight for the 3 months prior to screening (maximum 5% body weightgain and/or loss)

Exclusion Criteria:

• Have a history or diagnosis of any type of diabetes mellitus (Type 1 diabetes [T1D],T2D, or rare forms of diabetes)

• Have obesity induced by other endocrinologic disorders (e.g., Cushing's syndrome) ordiagnosed monogenetic or syndromic forms of obesity (e.g., melanocortin-4 receptordeficiency or Prader-Willi Syndrome)

• Participation in unbalanced/extreme diets or in an organized weight reductionprogram within 3 months of the screening visit or planning to engage in such dietsor programs during the study

• Prior or planned surgical treatment for obesity

• Have a known, clinically significant gastric emptying abnormality

• Have poorly controlled hypertension, untreated renal artery stenosis, or evidence oflabile blood pressure including symptomatic postural hypotension

• Have any of the following cardiovascular conditions within 3 months prior toscreening: Acute myocardial infarction; Cerebrovascular accident (stroke)/transientischemic attack; Unstable angina; Hospitalization due to congestive heart failure.

• Have a history of acute or chronic pancreatitis

• Have a history of significant active or unstable major depressive disorder (MDD) orother severe psychiatric disorder (e.g., schizophrenia, bipolar disorder, or otherserious mood or anxiety disorder), or had a suicide attempt within the last 1 yearof screening