Efficacy Comparison of Itraconazole Pulse Therapy and Terbinafine Therapy in Treatment of Tinea Capitis in Children.

Last updated: November 21, 2025
Sponsor: Muhammad Aamir Latif
Overall Status: Completed

Phase

N/A

Condition

Fungal Infections

Scalp Disorders

Treatment

Terbinafine

Itraconazole

Clinical Study ID

NCT07068256
DRSAIMA-JHLAHORE
  • Ages 1-13
  • All Genders

Study Summary

Several studies globally have assessed the efficacy of terbinafine and itraconazole in the treatment of tinea capitis, but local data in this regard is scarce. Therefore, this study was planned with the aim of assessing the difference between the therapeutic efficacy of itraconazole pulse therapy and terbinafine in children with tinea capitis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Any gender

  • Aged 1-13 years

  • With KOH mount positive before start of treatment

  • Duration of disease more than 1 month

Exclusion

Exclusion Criteria:

  • KOH mount negative before starting the treatment

  • Topical treatment with antifungal agents within past 4 weeks

  • Systemic treatment with antifungal agents within past 4 weeks

  • Patients with active liver disease

  • Patients with elevated liver enzymes

Study Design

Total Participants: 164
Treatment Group(s): 2
Primary Treatment: Terbinafine
Phase:
Study Start date:
April 01, 2025
Estimated Completion Date:
September 30, 2025

Study Description

The existing literature carries varying results between the effectiveness of itraconazole pulse therapy and continuous terbinafine therapy in treating tinea capitis, and local data in this regard is also scarce. The findings of this study would not only add to the statistics but would also help clinicians to offer a treatment modality in pediatric tinea capitis, which should have better efficacy, a low incidence of side effects, and better patient compliance.

Connect with a study center

  • Jinnah Hospital/Allama Iqbal Medical College

    Lahore, Punjab 54700
    Pakistan

    Site Not Available

  • Jinnah Hospital/Allama Iqbal Medical College

    Lahore 1172451, Punjab Province 1167710 54700
    Pakistan

    Site Not Available

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