Safety, Tolerability and Efficacy of Trichostatin A in Patients With Mild to Severe Onychomycosis

Inclusion Criteria:

• Willingness to provide signed and dated written voluntary informed consent.

• Adults with diagnosis of mild-to-severe DLSO/DSO affecting at least one greattoenail.

• Positive microscopic examination with KOH for dermatophyte hyphae.

• Positive dermatophyte culture or mixed dermatophyte/Candida culture.

Exclusion Criteria:

• Presence of other toenail infection.

• Any disease or condition that may interfere with the evaluation including otherconditions that affect the toenails or significant active tinea pedis.

• History of other significant chronic fungal disease, psoriasis, lichen planus or useof drug medications for those indications 6 months prior to screening and during thestudy.

• Participation in a previous clinical trial 3 months prior to screening orparticipation in a research study concurrent with this study.

• Current or planned pregnancy during the trial period.