Lumbar Spinal Stenosis and Central Sensitization

Phase

N/A

Condition

Spinal Stenosis

Spondylolisthesis

Treatment

N/A

Clinical Study ID

NCT07001982

Karabuk-2325

Ages 45-80
All Genders

Study Summary

Lumbar spinal stenosis (LSS) functionally limits individuals by causing pain in both the waist and the legs during activity and walking. Pain is, therefore, an important problem for patients. Pain lasts for years in LSS and thus becomes chronically persistent. As a result, persistent pain can cause sensitization due to a decrease in the pain threshold. This condition affects patients not only biomedically but also biopsychosocially. For this reason, various sleep disorders and mood disorders can develop in patients. Therefore, this study aimed to examine the relationship between central sensitization and pain, disability, sleep and depression in patients with LSS.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Diagnosed with lumbar spinal stenosis by MRI,
The ages of 45-80,
Low back and/or leg pain that has persisted for at least 3 months
Volunteer to participate in the study

Exclusion

Exclusion Criteria:

Patients who did not agree to participate in the study,
Those with a history of serious neurological diseases such as Parkinson's,hemiplegia, multiple sclerosis,
Those who had undergone surgery in the lumbar region within the last year,
Those with advanced joint disease in the lower extremity,
Those with malignancy in the spine,
Those who had a previous operation for the lower extremity,
Those who had a pain or disability in other musculoskeletal joints,
Those who had a psychological disorder or peripheral vascular disease
Those who had any concurrent serious medical condition, including sepsis or cancer
Those who did not cooperate well were not included in the study.

Study Design

June 17, 2025

December 15, 2025

Study Description

Lumbar spinal stenosis (LSS) functionally limits individuals by causing pain in both the waist and the legs during activity and walking. In particular, the pain in LSS lasts for years and becomes chronic and can cause persistent and disturbing sensitization. This situation may be associated with decreased pain threshold and allodynia. Various studies show that sensitization can affect individuals biomedically and may lead to important health problems. Some of these are sleep and depression problems. Sleep and a healthy mentality are important for continuing daily activities and preserving quality of life. However, when the literature is examined, it is seen that central sensitization and the parameters that may be related to this have not been examined sufficiently. Therefore, the aim of this study is to examine the relationship between central sensitization and pain, disability, sleep and depression in patients with LSS.

Connect with a study center

Karabuk University
Karabük, 78000
Turkey
Active - Recruiting

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